Document Detail

Acute Necrotizing Pancreatitis in the Setting of CMV Viremia and AIDS: A Case Report and Review of Literature from 1980 to 2012.
MedLine Citation:
PMID:  23183408     Owner:  NLM     Status:  In-Data-Review    
CONTEXT: Cytomegalovirus (CMV)-induced pancreatitis in patients with AIDS is a known entity with poor prognosis.
CASE REPORT: We report a case of a 43-year-old woman with AIDS and CMV viremia who was evaluated for hypotension and found to have severe necrotizing pancreatitis. The authors have also conducted a MEDLINE search for CMV-induced pancreatitis from 1980 to 2012 and reviewed the pertinent results.
DISCUSSION: Until mid-1990s in the United States, pancreatitis due to CMV was mainly diagnosed at autopsy in AIDS patients. However, presumably due to the advent of antiretroviral therapy, there has since been a significant decline in the number of reported cases among these individuals. Rather, our review revealed that the occurrence of CMV-induced pancreatitis has since been described in a variety of clinical settings, ranging from patients on corticosteroid therapy to immunocompetent persons.
CONCLUSIONS: Clinicians need a high index of suspicion to timely diagnose CMV-induced pancreatitis as patients often present with non-specific signs and symptoms. As it occurred in our case, early intervention is crucial and may alter the outcome in such patients.
Stephen Osiro; Raza Muhammad; Jose Ruiz; Anatole Sladen; Njambi Mathenge; Kevin J Tiwari
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Publication Detail:
Type:  Journal Article     Date:  2012-11-10
Journal Detail:
Title:  JOP : Journal of the pancreas     Volume:  13     ISSN:  1590-8577     ISO Abbreviation:  JOP     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101091810     Medline TA:  JOP     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  705-11     Citation Subset:  IM    
Department of Medicine, Woodhull Medical Center. Brooklyn, NY, USA.
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