Document Detail

Acute myocardial infarction is reflected in salivary matrix metalloproteinase-8 activation level.
MedLine Citation:
PMID:  21091346     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study is to compare salivary and serum biomarker levels and degrees of matrix metalloproteinase (MMP) activation between patients with acute myocardial infarction (AMI) and systemically healthy patients (non-AMI) with similar periodontal conditions.
METHODS: A total of 92 patients (47 AMI and 28 non-AMI patients with gingivitis or periodontitis; and 17 systemically and periodontally healthy patients as a control group) were recruited. Clinical periodontal measurements were recorded; stimulated whole saliva and serum samples were collected. AMI patients were clinically examined within 3 to 4 days after admission to the coronary care unit. Saliva samples were analyzed for levels of MMP-8, MMP-7, and tissue inhibitor of matrix metalloproteinase (TIMP)-1. Serums were tested for MMP-8, MMP-9, TIMP-1, and TIMP-2 levels by immunofluorometric assay and enzyme-linked immunosorbent assay. Molecular forms and degree of activation of salivary MMP-8, MMP-9, and MMP-13 were analyzed by computer-scanned immunoblots.
RESULTS: Total salivary MMP-8 assessed by immunofluorometric assay method and immunoblot densitometric units was higher in non-AMI than in AMI patients' saliva, but a significantly higher percentage of AMI patients' MMP-8 was activated polymorphonuclear leukocyte (PMN) type (P <0.001) regardless of periodontal diagnosis.Serum MMP-8, MMP-9, and TIMP-1 levels were significantly higher in AMI (for all markers and all comparisons,P <0.05). Characteristic for AMI was dominance of active PMN MMP-8 in saliva [corrected].
Eralp Buduneli; Päivi Mäntylä; Gülnur Emingil; Taina Tervahartiala; Pirkko Pussinen; Nezihi Barış; Azem Akıllı; Gül Atilla; Timo Sorsa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-23
Journal Detail:
Title:  Journal of periodontology     Volume:  82     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-28     Completed Date:  2011-09-22     Revised Date:  2011-10-12    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  716-25     Citation Subset:  D; IM    
Department of Periodontology, School of Dentistry, Ege University, İzmir, Turkey.
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MeSH Terms
Biological Markers / analysis,  blood
Blotting, Western
Chronic Periodontitis / complications,  enzymology
Gingival Hemorrhage / classification
Gingivitis / complications,  enzymology
Matrix Metalloproteinase 13 / analysis
Matrix Metalloproteinase 7 / analysis
Matrix Metalloproteinase 8 / analysis*,  blood
Matrix Metalloproteinase 9 / analysis,  blood
Middle Aged
Myocardial Infarction / complications,  enzymology*
Periodontal Attachment Loss / classification
Periodontal Index
Periodontal Pocket / classification
Periodontitis / complications,  enzymology
Saliva / enzymology*
Salivary Proteins and Peptides / analysis*
Tissue Inhibitor of Metalloproteinase-1 / analysis,  blood
Tissue Inhibitor of Metalloproteinase-2 / blood
Reg. No./Substance:
0/Biological Markers; 0/Salivary Proteins and Peptides; 0/Tissue Inhibitor of Metalloproteinase-1; 127497-59-0/Tissue Inhibitor of Metalloproteinase-2; EC 3.4.24.-/MMP13 protein, human; EC 3.4.24.-/MMP8 protein, human; EC 3.4.24.-/Matrix Metalloproteinase 13; EC protein, human; EC Metalloproteinase 7; EC Metalloproteinase 8; EC Metalloproteinase 9
Erratum In:
J Periodontol. 2011 Aug;82(8):1219

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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