| Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma: A Case Report and Review of the Literature. | |
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MedLine Citation:
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PMID: 22953080 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Primary myelofibrosis (formerly known as chronic idiopathic myelofibrosis), has the lowest incidence amongst the chronic myeloproliferative neoplasms and is characterized by a rather short median survival and a risk of progression to acute myeloid leukemia (AML) noted in a small subset of the cases, usually as a terminal event. As observed with other chronic myeloproliferative neoplasms, the bone marrow biopsy may harbor small lymphoid aggregates, often assumed reactive in nature. In our paper, we present a 70-year-old Caucasian male who was diagnosed with primary myelofibrosis, and after 8 years of followup and therapy developed an AML. The small lymphoid aggregates noted in his bone marrow were neoplastic in nature and represented bone marrow involvement by a CD5-negative mantle cell lymphoma (MCL) that presented without any associated lymphadenopathy. We reviewed the English medical literature to identify a single case report of simultaneous association of AML and a MCL in the bone marrow. The unusual association presented here suggests an increase in observer awareness to apparently benign lymphoid aggregates in chronic myeloproliferative neoplasms. |
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Authors:
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Diana O Treaba; Salwa Khedr; Shamlal Mangray; Cynthia Jackson; Jorge J Castillo; Eric S Winer |
Publication Detail:
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Type: Journal Article Date: 2012-08-02 |
Journal Detail:
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Title: Case reports in hematology Volume: 2012 ISSN: 2090-6579 ISO Abbreviation: Case Rep Hematol Publication Date: 2012 |
Date Detail:
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Created Date: 2012-09-06 Completed Date: 2012-09-06 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 101576456 Medline TA: Case Rep Hematol Country: United States |
Other Details:
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Languages: eng Pagination: 875039 Citation Subset: - |
Affiliation:
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Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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