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Acute Myeloid Leukemia Evolving from JAK 2-Positive Primary Myelofibrosis and Concomitant CD5-Negative Mantle Cell Lymphoma: A Case Report and Review of the Literature.
MedLine Citation:
PMID:  22953080     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Primary myelofibrosis (formerly known as chronic idiopathic myelofibrosis), has the lowest incidence amongst the chronic myeloproliferative neoplasms and is characterized by a rather short median survival and a risk of progression to acute myeloid leukemia (AML) noted in a small subset of the cases, usually as a terminal event. As observed with other chronic myeloproliferative neoplasms, the bone marrow biopsy may harbor small lymphoid aggregates, often assumed reactive in nature. In our paper, we present a 70-year-old Caucasian male who was diagnosed with primary myelofibrosis, and after 8 years of followup and therapy developed an AML. The small lymphoid aggregates noted in his bone marrow were neoplastic in nature and represented bone marrow involvement by a CD5-negative mantle cell lymphoma (MCL) that presented without any associated lymphadenopathy. We reviewed the English medical literature to identify a single case report of simultaneous association of AML and a MCL in the bone marrow. The unusual association presented here suggests an increase in observer awareness to apparently benign lymphoid aggregates in chronic myeloproliferative neoplasms.
Authors:
Diana O Treaba; Salwa Khedr; Shamlal Mangray; Cynthia Jackson; Jorge J Castillo; Eric S Winer
Publication Detail:
Type:  Journal Article     Date:  2012-08-02
Journal Detail:
Title:  Case reports in hematology     Volume:  2012     ISSN:  2090-6579     ISO Abbreviation:  Case Rep Hematol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-06     Completed Date:  2012-09-06     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  101576456     Medline TA:  Case Rep Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  875039     Citation Subset:  -    
Affiliation:
Department of Pathology and Laboratory Medicine, Rhode Island Hospital, The Warren Alpert Medical School, Brown University, Providence, RI 02903, USA.
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