Document Detail


Acute mesenteric ischemia induced by ligation of porcine superior mesenteric vein: multidetector CT evaluations.
MedLine Citation:
PMID:  20646939     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: To evaluate multidetector computed tomography (MDCT) for detecting the early changes and dynamic evolution of acute mesenteric ischemia (AMI) induced by the ligation of superior mesenteric vein (SMV) in an experimental porcine model.
MATERIALS AND METHODS: Twelve pigs were randomly assigned to three experimental groups, and one control group with three pigs in each group. After laparotomy, the SMV was separated and ligated in nine pigs and separated without ligation in three controls. MDCT pre- and postcontrast with arterial, venous, and delayed phase scans, and CT angiography reconstructions of mesenteric vessels were carried out at preoperation, 6 hours, 12 hours, and 18 hours after ligation. The findings of mesenteric vessels, bowel, abdominal cavity at pre- and postoperation, and dynamic evolution were correlated with pathology.
RESULTS: AMI-induced pathological changes were identified in all nine experimental pigs. MDCT angiography clearly delineated main trunk of the SMV, peripheral major and minor tributaries up to brushy vasa recta, and the location and shape of ligations. The early ischemic findings were bowel wall thickening, mesenteric edema, ascites, and pronounced bowel enhancement. Superior mesenteric artery and its major branches appeared spasm with poor filling and delayed and prolonged visualization. SMV and its tributaries were poorly delineated with delayed opacification. We also saw thinning of bowel wall, dilatating bowel with fluid, aggravating mesenteric edema and ascites, and poor enhanced bowel over time.
CONCLUSION: MDCT detects early changes of mesenteric ischemia and its evolution after ligation of porcine SMV, and may find application in early diagnosis of human venous occlusive AMI.
Authors:
Zuo Hua Tang; Jin Wei Qiang; Xiao Yuan Feng; Ruo Kun Li; Rong Xun Sun; Xuan Guang Ye
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Publication Detail:
Type:  Journal Article     Date:  2010-06-19
Journal Detail:
Title:  Academic radiology     Volume:  17     ISSN:  1878-4046     ISO Abbreviation:  Acad Radiol     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-09     Completed Date:  2011-01-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1146-52     Citation Subset:  IM    
Copyright Information:
Copyright 2010 AUR. Published by Elsevier Inc. All rights reserved.
Affiliation:
Eye and ENT Hospital, Fudan University, Shanghai 200040, China; Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Disease Models, Animal*
Humans
Ischemia / radiography*
Ligation
Mesenteric Vascular Occlusion / radiography*
Mesenteric Veins / radiography*,  surgery*
Reproducibility of Results
Sensitivity and Specificity
Swine
Tomography, X-Ray Computed / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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