| Acute meningitis prognosis using cerebrospinal fluid interleukin-6 levels. | |
| | |
MedLine Citation:
|
PMID: 22142673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Improved diagnostic tests would aid in diagnosing and treating community-acquired meningitis. OBJECTIVE: To analyze the diagnostic value of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF) of patients presenting with symptoms of acute meningitis. MATERIAL AND METHODS: In a 6-month prospective, observational, cross-sectional emergency department (ED) study, serum and CSF samples were obtained from all patients with a headache and fever in whom the physician suspected meningitis. Patients were excluded if computed tomography findings contraindicated a lumbar puncture, if they had bleeding disorders, or if their serum indicated bleeding. IL-6 levels were measured and compared in patients with (Group A) and without (Group B) bacterial meningitis. RESULTS: Samples were obtained from 53 patients, of whom 40 were ultimately found to have meningitis. These 40 patients averaged 49.6 ± 21.9 years, with number of men 18 (45%), hospitalizations 21 (52%), mortality 3 (.07%), and IL-6 average rating 491 (median: 14.5; range 0000-6000). Findings in the two groups were: Group A (with meningitis): n = 13, average IL-6 level: 1495 (median: 604; 25/75 percentiles: 232.5-2030; 95% confidence interval [CI] 371.7-2618.6; range 64-6000). Group B (with aseptic meningitis): n = 27, average IL-6 level: 7.34 (median: 5; 25/75 percentiles: 0.0/15.1; 95% CI 3.94-10.73; range 0-23.6). Mann-Whitney rank sum test: p < 0.0001. CONCLUSIONS: In patients with acute bacterial meningitis, CSF cytokine concentrations are elevated. Measuring CSF inflammatory cytokine levels in patients with acute meningitis could be a valuable ED diagnostic tool. Using this tool could improve the prognosis of patients with bacterial meningitis by allowing more rapid initiation of antibiotic treatment. |
| | |
Authors:
|
Jorge Alejandro Vázquez; Maria del Carmen Adducci; Carlos Coll; Daniel Godoy Monzón; Kenneth V Iserson |
Related Documents
:
|
10593793 - Management of airway manifestations of relapsing polychondritis: case reports and revie... 1190613 - Respiratory complications of overdose with sedative drugs. 8513393 - A serial study of psychometric and magnetic resonance imaging changes in multiple scler... |
Publication Detail:
|
Type: Journal Article Date: 2011-12-03 |
Journal Detail:
|
Title: The Journal of emergency medicine Volume: 43 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-08-13 Completed Date: 2013-02-14 Revised Date: 2013-03-21 |
Medline Journal Info:
|
Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: United States |
Other Details:
|
Languages: eng Pagination: 322-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
|
Emergency Department, Hospital Italiano de San Justo, Buenos Aires, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adolescent Adult Aged Cross-Sectional Studies Emergency Service, Hospital Female Fever / etiology Headache / etiology Hospitalization Humans Interleukin-6 / cerebrospinal fluid* Male Meningitis, Aseptic / cerebrospinal fluid*, diagnosis* Meningitis, Bacterial / cerebrospinal fluid*, diagnosis* Meningitis, Haemophilus / cerebrospinal fluid, diagnosis Meningitis, Listeria / cerebrospinal fluid, diagnosis Meningitis, Meningococcal / cerebrospinal fluid, diagnosis Meningitis, Pneumococcal / cerebrospinal fluid, diagnosis Middle Aged Predictive Value of Tests Prognosis Prospective Studies Statistics, Nonparametric Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Succinylcholine-induced Hyperkalemia in a Patient with Multiple Sclerosis.
Next Document: Usefulness of Severity Scores in Patients with Suspected Infection in the Emergency Department: A Sy...