| Acute MDMA administration alters the distribution and circadian rhythm of wheel running activity in the rat. | |
| | |
MedLine Citation:
|
PMID: 20816766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Ecstasy users report a number of adverse events following use including disturbed sleep. Previous research has suggested that MDMA affects the circadian system, however, the acute effects following a single, moderate dose have not been well characterised. The current study investigated how MDMA affected the circadian system, as measured by the amount and temporal distribution of wheel-running activity in male rats (n=90), housed individually under a 12-12 h light-dark (LD) cycle prior to treatment. MDMA (5 or 10 mg/kg) or saline was administered in a single i.p. injection during the light phase of the LD cycle and post-treatment activity was monitored during subsequent LD cycles (Experiment 1), or under constant darkness (Experiment 2). MDMA treatment disrupted wheel running activity in both experimental paradigms. In Experiment 1, 10 mg/kg MDMA significantly increased the amount of activity during the rest phase on the day of treatment and 1-day post treatment. This was accompanied by a change in the distribution of activity across the LD cycle during the first 24 h period after treatment, without a change in the overall daily activity level. Experiment 2 found that MDMA affected the circadian system as reflected by changes in the duration of the active phase, tau and activity offset. As a single dose of MDMA was able to disrupt the circadian rhythmicity of locomotor activity, this finding has implications for other behaviours that are under circadian control including the sleep/wake cycle. |
| | |
Authors:
|
Rowan P Ogeil; Shantha M W Rajaratnam; Jennifer R Redman; Jillian H Broadbear |
Related Documents
:
|
8653396 - Inhibitor of protein synthesis phase-shifts the circadian oscillator and inhibits the l... 1583606 - Fmrfamide modulates the action of phase shifting agents on the ocular circadian pacemak... 2142196 - Phase transitions and critical fluctuations in the visual coordination of rhythmic move... 2292146 - Electrical activity of the human uterus in vivo in the phases of the menstrual cycle. 22414076 - Time-frequency analysis of phonocardiogram signals using wavelet transform: a comparati... 21622636 - A quantitative method for measuring forces applied by nail braces. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-26 |
Journal Detail:
|
Title: Brain research Volume: 1359 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-15 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 128-36 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
|
School of Psychology and Psychiatry, Monash University, Victoria, Australia. Rowan.Ogeil@monash.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Circadian Rhythm / drug effects* Hallucinogens / pharmacology* Male Motor Activity / drug effects* N-Methyl-3,4-methylenedioxyamphetamine / pharmacology* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Hallucinogens; 42542-10-9/N-Methyl-3,4-methylenedioxyamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regulation of endogenous conductances in GnRH neurons by estrogens.
Next Document: Pharmacological characterization of [(125)I]CHIBA-1006 binding, a new radioligand for ?7 nicotinic a...