Document Detail

Acute lower urinary tract symptoms after prostate brachytherapy with cesium-131.
MedLine Citation:
PMID:  20627283     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate the severity and interval to resolution of the acute lower urinary tract symptoms in men undergoing prostate brachytherapy (PB) with cesium-131 ((131)Cs).
METHODS: A longitudinal, prospective study of patients who had undergone PB with (131)Cs at our institution and had a minimum of 6 months of follow-up was performed. Urinary symptoms were assessed using the Expanded Prostate Cancer Index Composite. Patients were asked to complete a survey preoperatively and at 2 weeks and 1, 3, and 6 months postoperatively.
RESULTS: The first 152 patients who underwent PB with (131)Cs at our institution were included in the present study. The mean Expanded Prostate Cancer Index Composite urinary summary score decreased significantly from baseline (86.4) at 2 weeks (59.2) and 1 month (62.2) after PB. These scores returned to the clinical baseline by 3 months (79.6) and to the statistical baseline by 6 months (84.0) after PB. The urinary subscales (function, bother, incontinence, irritative/obstructive) followed the same course in returning to the clinical and statistical baseline values. Similar patterns were seen when patients were stratified by PB as monotherapy. For patients undergoing combination therapy, the mean Expanded Prostate Cancer Index Composite scores returned to the clinical and statistical baseline values by 3 months after their procedure.
CONCLUSIONS: In patients undergoing PB with (131)Cs, the postprocedure lower urinary tract symptoms generally returned to the clinical baseline by 3 months and the statistical baseline value by 6 months after PB.
Bruce L Jacobs; Ryan P Smith; Sushil Beriwal; Ronald M Benoit
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Urology     Volume:  76     ISSN:  1527-9995     ISO Abbreviation:  Urology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1143-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15232, USA.
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MeSH Terms
Acute Disease
Brachytherapy / adverse effects*
Cesium Radioisotopes / adverse effects*,  therapeutic use
Prostatic Neoplasms / radiotherapy*
Radiotherapy Dosage
Urination Disorders / etiology*
Reg. No./Substance:
0/Cesium Radioisotopes
Comment In:
Urology. 2010 Nov;76(5):1147; author reply 1148   [PMID:  21056258 ]
Urology. 2010 Nov;76(5):1148; author reply 1148-9   [PMID:  21056260 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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