Document Detail

Acute liver failure with thyrotoxicosis treated with liver transplantation.
MedLine Citation:
PMID:  23337142     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We describe a young woman with previously undiagnosed thyrotoxicosis who presented with acute liver failure (ALF).
METHODS: We present a case report and review the relevant literature.
RESULTS: An extensive evaluation excluded possible causes of ALF other than thyrotoxicosis. The management of thyrotoxicosis posed several unique challenges in the setting of ALF, particularly because we did not want to use potentially hepatotoxic thionamides. The patient was treated with prednisone and propranolol and was started on potassium iodide when she was listed for liver transplantation. She underwent an uncomplicated liver transplant and subsequent thyroidectomy and is doing well.
CONCLUSION: This well-characterized case describes thyrotoxicosis as a possible cause of ALF after thoroughly excluding other possible causes and illustrates the challenges of simultaneously managing both disorders. To our knowledge, this is the first report of ALF possibly resulting from untreated thyrotoxicosis that was successfully treated with liver transplantation.
Matthew D Cascino; Brian McNabb; David G Gardner; Kenneth A Woeber; Alyson N Fox; Bruce Wang; Oren K Fix
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists     Volume:  19     ISSN:  1934-2403     ISO Abbreviation:  Endocr Pract     Publication Date:    2013 May-Jun
Date Detail:
Created Date:  2013-07-02     Completed Date:  2014-02-19     Revised Date:  2014-04-29    
Medline Journal Info:
Nlm Unique ID:  9607439     Medline TA:  Endocr Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e57-60     Citation Subset:  IM    
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MeSH Terms
Liver Failure, Acute / diagnosis*,  drug therapy,  surgery*
Liver Transplantation*
Potassium Iodide / therapeutic use
Prednisone / therapeutic use
Propranolol / therapeutic use
Thyrotoxicosis / diagnosis*,  drug therapy,  surgery*
Treatment Outcome
Grant Support
Reg. No./Substance:
1C4QK22F9J/Potassium Iodide; 9Y8NXQ24VQ/Propranolol; VB0R961HZT/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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