Document Detail

Acute Exercise and Training Alter Blood Lipid and Lipoprotein Profiles Differently in Overweight and Obese Men and Women.
MedLine Citation:
PMID:  22421926     Owner:  NLM     Status:  Publisher    
Our purpose was to elucidate effects of acute exercise and training on blood lipids-lipoproteins, and hsCRP in overweight/obese men (n=10) and women (n=8); age, BMI, body fat percentage, and VO(2)max were (mean±SEM): 45±2.5 yr, 31.9±1.4 kg·m(-2), 41.1±1.5%, and 25.2±1.3 mLO(2)·kg(-1) min(-1). Before exercise training subjects performed an acute exercise session on a treadmill (70% VO(2)max, 400 kcal energy expenditure), followed by 12-wks of endurance exercise training (land-based or aquatic-based treadmill): 3 sessions wk(-1), progressing to 500 kcal session(-1) during which subjects maintained accustomed dietary habits. After training, the acute exercise session was repeated. Blood samples, obtained immediately prior to and 24h after acute exercise sessions, were analyzed for serum lipids, lipoproteins, and hsCRP adjusted for plasma volume shifts. Exercise training increased VO(2)max (+3.67 mLO(2)·kg(-1) min(-1), p<0.001) and reduced body weight (-2.7 kg, p<0.01). Training increased HDL and HDL(2b)-cholesterol (HDL-C) concentrations (+3.7, and +2.4 mg·dL(-1), p<0.05) and particle numbers (+588, and +206 nmol·L(-1), p<0.05) in men. In women despite no change in total HDL-C, subfractions shifted from HDL(3)-C (-3.2, p<0.01) to HDL(2b)-C (+3.5, p<0.05) and HDL2a-C (+2.2 mg·dL(-1), p<0.05), with increased HDL2b particle number (+313 nmol·L(-1), p<0.05). Training reduced LDL(3) concentration and particle number in women (-1.6 mg·dL(-1), and -16 nmol·L(-1), p<0.05). Acute exercise reduced the TC: HDL-C ratio in men (-0.16, p<0.01) and increased hsCRP in all subjects (+0.05 mg·dL(-1), p<0.05), regardless of training. Training did not affect acute exercise responses. Our data support the efficacy of endurance training, without dietary intervention, to elicit beneficial changes in blood lipids-lipoproteins in obese men and women.
N P Greene; S E Martin; S F Crouse
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-16
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-7381     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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