Document Detail

Acute Elevation of Triglycerides Increases Left Ventricular Contractility and Alters Ventricular-Vascular Interaction.
MedLine Citation:
PMID:  21490326     Owner:  NLM     Status:  Publisher    
Acute elevation of circulating lipids, such as the postprandial state, contributes to increased cardiovascular risk. However, the effect of acutely elevated triglycerides on arterial and left ventricular function is not completely understood. We aimed to assess whether an acute increase in triglycerides affects ventricular-vascular interaction. Fifteen healthy men (aged 49±8yrs) underwent blinded, randomized infusion of saline and intravenous fat emulsion to acutely raise plasma triglycerides. All subjects underwent both randomization trials, in random order on two separate days. Ventricular-vascular interaction measures were recorded by tonometry (central blood pressure) and echocardiography (left ventricular volumes, strain and strain rate) at baseline and after 1 hour infusion. Net ventricular-vascular interaction was defined by the E(A)/E(LV) ratio (E(A); effective arterial and E(LV); end-systolic elastance). Compared to saline, infusion of intravenous fat emulsion increased triglycerides and free fatty acids (delta P<0.001 for both) and improved left ventricular contractility (delta E(LV), end-systolic volume and strain rate; P<0.05 for all). However, arterial function was unchanged (delta E(A), brachial and central blood pressure; P>0.05 for all). Overall, E(A)/E(LV) was decreased by infusion of intravenous fat emulsion (P=0.004) but not saline (P>0.05, P=0.001 for delta between trials). We conclude that intravenous fat emulsion and acute elevation of blood lipids (including triglycerides and free fatty acids) alters ventricular-vascular interaction by increasing left ventricular contractility without affecting arterial load. These findings may have implications for cardiovascular responses to parenteral nutrition.
David J Holland; Dominique Erne; Karam Kostner; Rodel Leano; Brian A Haluska; Thomas H Marwick; James E Sharman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-13
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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