Document Detail


Acute Elevation of Triglycerides Increases Left Ventricular Contractility and Alters Ventricular-Vascular Interaction.
MedLine Citation:
PMID:  21490326     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acute elevation of circulating lipids, such as the postprandial state, contributes to increased cardiovascular risk. However, the effect of acutely elevated triglycerides on arterial and left ventricular function is not completely understood. We aimed to assess whether an acute increase in triglycerides affects ventricular-vascular interaction. Fifteen healthy men (aged 49±8yrs) underwent blinded, randomized infusion of saline and intravenous fat emulsion to acutely raise plasma triglycerides. All subjects underwent both randomization trials, in random order on two separate days. Ventricular-vascular interaction measures were recorded by tonometry (central blood pressure) and echocardiography (left ventricular volumes, strain and strain rate) at baseline and after 1 hour infusion. Net ventricular-vascular interaction was defined by the E(A)/E(LV) ratio (E(A); effective arterial and E(LV); end-systolic elastance). Compared to saline, infusion of intravenous fat emulsion increased triglycerides and free fatty acids (delta P<0.001 for both) and improved left ventricular contractility (delta E(LV), end-systolic volume and strain rate; P<0.05 for all). However, arterial function was unchanged (delta E(A), brachial and central blood pressure; P>0.05 for all). Overall, E(A)/E(LV) was decreased by infusion of intravenous fat emulsion (P=0.004) but not saline (P>0.05, P=0.001 for delta between trials). We conclude that intravenous fat emulsion and acute elevation of blood lipids (including triglycerides and free fatty acids) alters ventricular-vascular interaction by increasing left ventricular contractility without affecting arterial load. These findings may have implications for cardiovascular responses to parenteral nutrition.
Authors:
David J Holland; Dominique Erne; Karam Kostner; Rodel Leano; Brian A Haluska; Thomas H Marwick; James E Sharman
Related Documents :
3941206 - Characterization of retrograde conduction by direct endocardial recording from an acces...
7686666 - Low-energy dc catheter ablation of left atrial ectopic tachycardia that had resulted in...
17017676 - Tachycardiomyopathy induced by ventricular premature complexes: complete recovery after...
23834756 - First report of atretic coronary sinus stenting in a 5-kg infant resulting in dramatic ...
18598096 - Relationship between haemoglobin a1c values and recurrent cardiac events: a retrospecti...
15378136 - Microvascular alterations after temporary coronary artery occlusion: the no-reflow phen...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-13
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CARDIOVASCULAR EFFECTS OF TREADMILL EXERCISE IN PHYSIOLOGICAL AND PATHOLOGICAL PRECLINICAL SETTINGS.
Next Document:  Effects of Alcohol Septal Ablation on Coronary Microvascular Function and Myocardial Energetics in H...