Document Detail


Acute Effects of Sildenafil on Uroflowmetric Parameters in Erectile Dysfunction Patients with and without Lower Urinary Tract Symptoms.
MedLine Citation:
PMID:  22492839     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: Using phosphodiesterase type 5 (PDE5) inhibitors in lower urinary tract symptoms (LUTS) patients still continues to draw attention. Despite clinical improvements in patients, it is still debatable whether urinary flow rates are increased or not. The aim of this study was to evaluate acute effects of sildenafil, a PDE5 inhibitor, on uroflowmetry parameters. Methods: 110 males, who have applied to our outpatient clinics, and had no history of alpha blocker and PDE5 inhibitor use, are included into study. Two uroflowmetries were performed within 24-72 hours without any treatments. Participants received 50 mg sildenafil at their third visits and uroflowmetry was repeated after 2 hours. A total of 102 males were included in analysis and baseline uroflowmetry values were compared with values obtained after sildenafil use. Findings: Mean age of 102 participants, who have attended all three visits (92.7%), was 52.1 ± 12.2 years. Mean of baseline maximal flow rate (Qmax) values were 17.1 ± 5.1 ml/sec, mean of Qmax after sildenafil was 18.2 ± 5.1 ml/sec; average flow rates (Qave) values at the baseline and after sildenafil were 9.5 ± 3.5 and 9.9 ± 3.5 ml/sec, respectively. Mean of postvoid residual urine (PVR) volume for baseline and after sildenafil were 31.2 ± 20.1 and 27.7 ± 18.4 ml, respectively. Statistically significant difference is determined between baseline and post-sildenafil values in terms of Qave and PVR values. Conclusion: Results of this study suggest that sildenafil has effect on uroflowmetric parameters on acute period.
Authors:
Metin I Oztürk; Orhan Koca; Zülfü Sertkaya; Muzaffer O Keles; Cevdet Kaya; Muhammet I Karaman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-5
Journal Detail:
Title:  Journal of andrology     Volume:  -     ISSN:  1939-4640     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106453     Medline TA:  J Androl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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