| Acute effects of salmeterol and fluticasone propionate alone and in combination on airway blood flow in patients with asthma. | |
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MedLine Citation:
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PMID: 21980058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The airway contains airway smooth muscle and airway vascular smooth muscle. The acute effects of inhaled long-acting β(2)-adrenergic agonists (LABAs) alone, or in combination with an inhaled glucocorticoid (ICS), on airway smooth muscle tone in asthma are known; however, to the best of our knowledge, their effect on airway vascular smooth muscle tone has not been investigated previously. The objective of this study was to investigate the immediate effects of a LABA and an ICS alone and in combination on airway blood flow (Qaw) as an index of airway vascular smooth muscle tone in patients with stable asthma. METHODS: Fourteen subjects with moderate asthma inhaled single doses of salmeterol (50 μg), fluticasone propionate (250 μg), salmeterol/fluticasone propionate (50/250 μg), or placebo; Qaw was measured before and serially for 240 min after drug administration. RESULTS: Mean Qaw increased after salmeterol and salmeterol/fluticasone propionate, with peaks at 60 min of 34% and 40%, respectively, and returned to baseline by 240 min after inhalation. Fluticasone propionate alone caused a transient decrease in mean Qaw. The maximal changes in Qaw, which occurred at different times, were 60% for salmeterol, 67% for salmeterol/fluticasone propionate, and -19% for fluticasone propionate (P < .05 vs placebo for all). CONCLUSIONS: The LABA salmeterol has an acute vasodilator action on the airway of subjects with stable asthma. The addition of fluticasone propionate, which by itself causes vasoconstriction, does not attenuate the salmeterol-induced vasodilation, suggesting that fluticasone propionate potentiates the vasodilator effect of salmeterol. The vasodilation could be of clinical benefit by promoting the vascular clearance of inflammatory mediators including spasmogens from the airway. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01231230; URL: www.clinicaltrials.gov. |
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Authors:
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Eliana S Mendes; Patricia Rebolledo; Adam Wanner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-10-06 |
Journal Detail:
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Title: Chest Volume: 141 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-03 Completed Date: 2012-06-25 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1184-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. emendes@med.miami.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01231230 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adult Airway Resistance / drug effects* Albuterol / analogs & derivatives*, therapeutic use Androstadienes / therapeutic use* Anti-Asthmatic Agents / therapeutic use* Asthma / drug therapy* Blood Flow Velocity / drug effects Bronchi / blood supply* Bronchodilator Agents / therapeutic use* Delayed-Action Preparations Double-Blind Method Drug Combinations Female Forced Expiratory Volume / drug effects Glucocorticoids / therapeutic use* Humans Male Middle Aged Muscle, Smooth / drug effects* Muscle, Smooth, Vascular / drug effects* Vasodilation / drug effects* Vital Capacity / drug effects Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Androstadienes; 0/Anti-Asthmatic Agents; 0/Bronchodilator Agents; 0/Delayed-Action Preparations; 0/Drug Combinations; 0/Glucocorticoids; 0/fluticasone, salmeterol drug combination; 18559-94-9/Albuterol; 89365-50-4/salmeterol; 90566-53-3/fluticasone |
| Comments/Corrections | |
Comment In:
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Chest. 2012 May;141(5):1134-6
[PMID:
22553257
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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