Document Detail


Acute effects of moxonidine on cardiac autonomic modulation.
MedLine Citation:
PMID:  20230461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Moxonidine, an imidazoline I1 receptor agonist, is a centrally acting antihypertensive agent having sympatholytic effect. However, there are only limited data regarding the effects of this drug on autonomic cardiac functions.
METHODS AND RESULTS: In this study we investigated the acute effects of moxonidine on cardiac autonomic modulation by heart rate variability (HRV) analysis. The effects of oral 0.4-mg moxonidine were studied on 11 healthy male volunteers in a randomized, double-blind, placebo controlled, and crossover study. After 15 minutes rest, time and frequency domain parameters of HRV were calculated from 5-minute continue electrocardiography recordings in supine position, during controlled respiration (15 breath/min) and during handgrip exercise before and 1 hour after taking placebo or moxonidine. Baseline parameters before taking placebo and moxonidine were similar (P > 0.05). Moxonidine, but not placebo, caused an increase in heart failure (HF) (119 +/- 21 vs 156 +/- 23, P = 0.029) and HFnu (39 +/- 4 vs 47 +/- 4, P = 0.033) and decrease in LFnu (61 +/- 4 vs 53 +/- 4, P = 0.033) and LF/HF ratio (1.96 +/- 0.36 vs 1.12 +/- 0.35, P = 0.010) in supine position compared with baseline parameters. However, there was no difference in other time or frequency domain parameters during controlled breathing and handgrip exercise either with moxonidine or placebo administration (P > 0.05). Single dose of moxonidine administration increases cardiovagal tone but parasympathetic and sympathetic autonomic maneuvers attenuated its short term effects on HRV in healthy male subjects.
Authors:
Dayimi Kaya; Irfan Barutcu; Ali Metin Esen; Atac Celik; Ersel Onrat
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2010-03-08
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  33     ISSN:  1540-8159     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-13     Completed Date:  2010-12-06     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-33     Citation Subset:  IM    
Affiliation:
Dr.Suat Seren Chest Disease and Surgery Education and Research Hospital, Department of Cardiology, Izmir, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antihypertensive Agents / pharmacology*
Autonomic Nervous System / drug effects,  physiology*
Cross-Over Studies
Double-Blind Method
Hand Strength
Heart / drug effects,  innervation*,  physiology
Heart Rate / drug effects*
Humans
Imidazoles / pharmacology*
Imidazoline Receptors / agonists*
Male
Respiration
Sympatholytics / pharmacology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Imidazoles; 0/Imidazoline Receptors; 0/Sympatholytics; 75438-57-2/moxonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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