Document Detail

The Acute Effects of L-arginine on Hormonal and Metabolic Responses During Submaximal Exercise in Trained Cyclists.
MedLine Citation:
PMID:  23319437     Owner:  NLM     Status:  Publisher    
L-arginine may enhance endurance performance mediated by two primary mechanisms including enhanced secretion of endogenous growth hormone (GH) and as a precursor of nitric oxide (NO); however, research in trained participants has been equivocal. The purpose was to investigate the effect of acute L-arginine ingestion on the hormonal and metabolic response during submaximal exercise in trained cyclists. Fifteen aerobically trained men (age: 28 ± 5 y; body mass: 77.4 ± 9.5 kg; height: 180.9 ± 7.9 cm; VO2max : 59.6 ± 5.9 ml·kg-1·min-1) participated in a randomized, double blind, crossover study. Subjects consumed L-arginine (ARG; 0.075 g·kg-1 body mass) or a placebo (PLA) prior to performing an acute bout of submaximal exercise (60 min at 80% of power output achieved at ventilatory threshold). The ARG condition significantly increased plasma L-arginine concentrations (~146%) while no change was detected in the PLA condition. There were no differences between conditions for GH, non-esterified fatty acids (NEFA), lactate, glucose, VO2, VCO2, RER, CHO oxidation, and NOx. There was reduced fat oxidation at the start of exercise (ARG: 0.36 ± 0.25 vs. PLA: 0.42 ± 0.23 g·min-1, p<0.05) and an elevated plasma glycerol concentrations at the 45 min time point (ARG: 340.3 vs. PLA: 288.5 μmol·L-1, p<0.05) after L-arginine consumption. In conclusion, the acute ingestion of L-arginine did not alter any hormonal, metabolic, or cardio-respiratory responses during submaximal exercise except for a small but significant increase in glycerol at the 45 min time point and a reduction in fat oxidation at the start of exercise.
Scott C Forbes; Vicki Harber; Gordon J Bell
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-8
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Faculty of Physical Education & Recreation, University of Alberta, Edmonton, Alberta, Canada.
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