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Acute Effects of Intracoronary Tirofiban on No-Reflow Phenomena in Patients With ST-Segment Elevated Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
MedLine Citation:
PMID:  25092681     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We evaluated the acute effect of intracoronary administration of tirofiban on no-reflow phenomenon in patients with ST-segment elevated myocardial infarction undergoing primary percutaneous coronary intervention. Consecutive patients (n = 162) were randomized into 2 groups based on whether intracoronary tirofiban was administered. After the administration of intracoronary tirofiban, thrombolysis in myocardial infarction (TIMI) flow grade significantly increased (P < .001) and successful reperfusion was achieved in 26 (32%) patients. In the placebo group, however, after the administration of intracoronary placebo the TIMI flow grade did not change (P = .070), and successful reperfusion was achieved only in 8 (10%) patients. In-hospital major adverse cardiac events (MACE) were significantly lower in the tirofiban group (36% vs 19%, P = .013). Intracoronary administration of tirofiban significantly improves TIMI flow grade and is associated with a lower in-hospital rate of MACE.
Authors:
Mahmut Akpek; Omer Sahin; Bahadir Sarli; Ahmet Oguz Baktir; Hayrettin Saglam; Serkan Urkmez; Ali Ergin; Abdurrahman Oguzhan; Huseyin Arinc; Mehmet G Kaya
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-4
Journal Detail:
Title:  Angiology     Volume:  -     ISSN:  1940-1574     ISO Abbreviation:  Angiology     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© The Author(s) 2014.
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