Document Detail


Acute effects of exercise and calorie restriction on triglyceride metabolism in women.
MedLine Citation:
PMID:  23073216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The mechanisms by which exercise reduces fasting plasma triglyceride (TG) concentrations in women and the effect of negative energy balance independent of muscular contraction are not known.The aim of this study was to evaluate the effects of equivalent energy deficits induced by exercise or calorie restriction on basal VLDL-TG metabolism in women.
METHODS: Eleven healthy women (age = 23.5 ± 2.7 yr, body mass index = 21.6 ± 1.4 kg·m-2; mean ± SD) underwent a stable isotopically labeled tracer infusion study to determine basal VLDL-TG kinetics after performing, in random order, three experimental trials on the previous day: (i) a single exercise bout (brisk walking at 60% of peak oxygen consumption for 123 ± 18 min, with a net energy expenditure of 2.06 ± 0.39 MJ, ∼500 kcal), (ii) dietary energy restriction of 2.10 ± 0.41 MJ, and (iii) a control day of isocaloric feeding and rest (zero energy balance).
RESULTS: Fasting plasma VLDL-TG concentration was approximately 30% lower after the exercise trial compared with the control trial (P < 0.001), whereas no significant change was detected after the calorie restriction trial (P = 0.297 vs control). Relative to the control condition, exercise increased the plasma clearance rate of VLDL-TG by 22% (P = 0.001) and reduced hepatic VLDL-TG secretion rate by approximately 17% (P = 0.042), whereas hypocaloric diet had no effect on VLDL-TG kinetics (P > 0.2).
CONCLUSION: (i) Exercise-induced hypotriglyceridemia in women manifests through a different mechanism (increased clearance and decreased secretion of VLDL-TG) than that previously described in men (increased clearance of VLDL-TG only), and (ii) exercise affects TG homeostasis by eliciting changes in VLDL-TG kinetics that cannot be reproduced by an equivalent diet-induced energy deficit, indicating that these changes are independent of the exercise-induced negative energy balance but instead are specific to muscular contraction.
Authors:
Elena Bellou; Aikaterina Siopi; Maria Galani; Maria Maraki; Yiannis E Tsekouras; Demosthenes B Panagiotakos; Stavros A Kavouras; Faidon Magkos; Labros S Sidossis
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  45     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-22     Completed Date:  2013-09-26     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  455-61     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / metabolism
Caloric Restriction*
Energy Metabolism
Exercise / physiology*
Fatty Acids / blood
Female
Humans
Insulin / blood
Lipoproteins, VLDL / blood*
Statistics, Nonparametric
Triglycerides / blood*
Young Adult
Grant Support
ID/Acronym/Agency:
P30 DK056341/DK/NIDDK NIH HHS; UL1 TR000071/TR/NCATS NIH HHS; UL1TR000071/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids; 0/Insulin; 0/Lipoproteins, VLDL; 0/Triglycerides; 0/very low density lipoprotein triglyceride
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