| Acute effects of cigarillo smoking. | |
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MedLine Citation:
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PMID: 21504888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Cigarillo smoking likely exposes users to many of the same toxicants (e.g., nicotine, carbon monoxide [CO]) as cigarette smoking. Yet, few controlled clinical laboratory studies evaluating of the effects of cigarillos exist. This study evaluated the cardiovascular response, toxicant exposure, subjective effects, and puffing topography of a popular cigarillo brand, Black & Mild (B&M). METHODS: Sixteen B&M smokers (M ± SD = 1.9 ± 2.5 cigarillos/day for 3.4 ± 3.5 years) participated in 2 counterbalanced conditions: lit (ACTIVE) or unlit (SHAM) B&M in which they completed two 10-puff smoking bouts (30-s interpuff intervals). RESULTS: Plasma nicotine concentrations for ACTIVE increased significantly from pre-smoking (M ± SEM = 2.0 ± 0.0 ng/ml) to 5 min after Bouts 1 (5.3 ± 0.8 ng/ml) and 2 (4.9 ± 0.9 ng/ml) but did not increase above 2.0 ± 0.0 ng/ml at any timepoint for SHAM. Heart rate increased significantly from pre- to post-smoking for ACTIVE but not for SHAM. Average expired-air CO levels, collapsed across time, were 14.3 ± 0.8 ppm for ACTIVE and 4.5 ± 0.2 ppm for SHAM. Neither condition reduced symptoms of nicotine/tobacco abstinence reliably, although ratings for some measures were significantly lower for ACTIVE than for SHAM. ACTIVE, but not SHAM, produced a variety of positive effects related to product sensory characteristics (e.g., "satisfying," "pleasant"). Smoking topography did not differ across the two conditions. Conclusions: Ten puffs from a B&M cigarillo deliver active doses of nicotine and considerable amounts of CO but do not suppress abstinence-induced withdrawal symptoms reliably. The nicotine delivery profile suggests that cigarillo smoking may promote nicotine/tobacco dependence and the CO exposure likely poses significant health risks. |
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Authors:
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Melissa D Blank; Aashir Nasim; Alton Hart; Thomas Eissenberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-04-18 |
Journal Detail:
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Title: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco Volume: 13 ISSN: 1469-994X ISO Abbreviation: Nicotine Tob. Res. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-08 Completed Date: 2012-02-08 Revised Date: 2012-09-27 |
Medline Journal Info:
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Nlm Unique ID: 9815751 Medline TA: Nicotine Tob Res Country: England |
Other Details:
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Languages: eng Pagination: 874-9 Citation Subset: IM |
Affiliation:
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Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284-2018, USA. blankmd@vcu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Carbon Monoxide / blood Female Heart Rate / drug effects Humans Male Middle Aged Nicotine / blood Smoking / adverse effects*, blood, physiopathology Virginia Young Adult |
| Chemical | |
Reg. No./Substance:
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54-11-5/Nicotine; 630-08-0/Carbon Monoxide |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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