Document Detail

Acute Dane particle suppression with recombinant leukocyte A interferon in chronic hepatitis B virus infection.
MedLine Citation:
PMID:  6631076     Owner:  NLM     Status:  MEDLINE    
The clinical, virologic, biochemical, and immunologic effects of a biosynthetic human leukocyte interferon, recombinant leukocyte A interferon (rIFN-A or HuIFN-alpha 2) are reported in nine patients with chronic hepatitis B virus infection and circulating Dane particle-associated polymerase activity. Eight-day courses of rIFN-A were given starting at a dose of 3 X 10(6) units per day and reaching 68 X 10(6) units per day in two patients. Major toxic side effects included fever, fatigue, gastrointestinal symptoms, myalgias, and headache. Most courses of rIFN-A were associated with a reduction in Dane particle-associated polymerase activity, but in no case was this change permanent. There were also changes in lymphocyte subpopulations at the higher dosage levels of rIFN-A. Because of the reproducible, statistically significant effect on viral replication, further study with this and other biosynthetic interferon species is warranted.
C I Smith; J Weissberg; L Bernhardt; P B Gregory; W S Robinson; T C Merigan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  148     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  907-13     Citation Subset:  AIM; IM    
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MeSH Terms
Chronic Disease
DNA, Recombinant
DNA-Directed DNA Polymerase / metabolism
Dose-Response Relationship, Drug
Hepatitis B / blood,  microbiology,  therapy*
Hepatitis B virus / drug effects*,  enzymology
Interferon Type I / adverse effects,  blood,  therapeutic use*
Leukocyte Count
Liver Function Tests
Middle Aged
Reg. No./Substance:
0/DNA, Recombinant; 0/Interferon Type I; EC DNA Polymerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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