| Acute coronary artery vasospasm associated with misoprostol for termination of pregnancy. | |
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MedLine Citation:
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PMID: 20224253 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostaglandin E(1) analogues, gemeprost and misoprostol, are the most widely used drugs for medical termination of pregnancy within the first two trimesters of pregnancy. Gemeprost has been reported to be associated with acute cardiovascular accidents in a few cases, but no adverse cardiovascular events have been reported with misoprostol. For this reason, misoprostol has been considered a potentially safer drug and is widely recommended as a first-choice drug in combination with mifepristone. We report a case of a 32-year-old woman with active smoking and obesity, who developed an episode of transient acute coronary artery vasospasm following the administration of intravaginal misoprostol. This report illustrates that misoprostol can also be associated with acute coronary events, although it remains to be evaluated whether the risk is similar or lower to gemeprost. |
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Authors:
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Miriam Illa; Mar Bennasar; Elisenda Eixarch; Raquel Berge; Carme Font; Montse Palacio |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-03-11 |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 27 ISSN: 1421-9964 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 174-7 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Maternal-Fetal Medicine, Institut Clínic de Ginecologia, Obstetrícia i Neonatologia (ICGON), Hospital Clinic, University of Barcelona, Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage,
adverse effects* Abortion, Induced / adverse effects* Adult Alprostadil / adverse effects, analogs & derivatives Analgesics / therapeutic use Chest Pain / drug therapy Coronary Vasospasm / chemically induced, diagnosis* Coronary Vessels / drug effects*, physiopathology Female Humans Ketoprofen / analogs & derivatives, therapeutic use Mifepristone / adverse effects Misoprostol / administration & dosage, adverse effects* Pregnancy Pregnancy Trimester, Second / drug effects Tromethamine / analogs & derivatives, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Analgesics; 0/dexketoprofen trometamol; 22071-15-4/Ketoprofen; 59122-46-2/Misoprostol; 64318-79-2/gemeprost; 745-65-3/Alprostadil; 77-86-1/Tromethamine; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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