Document Detail

Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia.
MedLine Citation:
PMID:  23616506     Owner:  NLM     Status:  MEDLINE    
Walnut consumption improves cardiovascular disease risk; however, to our knowledge, the contribution of individual walnut components has not been assessed. This study evaluated the acute consumption of whole walnuts (85 g), separated nut skins (5.6 g), de-fatted nutmeat (34 g), and nut oil (51 g) on postprandial lipemia, endothelial function, and oxidative stress. Cholesterol efflux (ex vivo) was assessed in the whole walnut treatment only. A randomized, 4-period, crossover trial was conducted in healthy overweight and obese adults (n = 15) with moderate hypercholesterolemia. There was a treatment × time point interaction for triglycerides (P < 0.01) and increased postprandial concentrations were observed for the oil and whole walnut treatments (P < 0.01). Walnut skins decreased the reactive hyperemia index (RHI) compared with baseline (P = 0.02) such that a difference persisted between the skin and oil treatments (P = 0.01). The Framingham RHI was maintained with the oil treatment compared with the skins and whole nut (P < 0.05). There was a treatment effect for the ferric reducing antioxidant potential (FRAP) (P < 0.01), and mean FRAP was greater with the oil and skin treatments compared with the nutmeat (P < 0.01). Cholesterol efflux increased by 3.3% following whole walnut consumption in J774 cells cultured with postprandial serum compared with fasting baseline (P = 0.02). Walnut oil favorably affected endothelial function and whole walnuts increased cholesterol efflux. These 2 novel mechanisms may explain in part the cardiovascular benefits of walnuts.
Claire E Berryman; Jessica A Grieger; Sheila G West; Chung-Yen O Chen; Jeffrey B Blumberg; George H Rothblat; Sandhya Sankaranarayanan; Penny M Kris-Etherton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-04-24
Journal Detail:
Title:  The Journal of nutrition     Volume:  143     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-21     Completed Date:  2013-07-22     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  788-94     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cholesterol / blood,  metabolism
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Endothelium, Vascular / physiopathology
Energy Intake
Heart Rate
Hypercholesterolemia / blood,  physiopathology*
Lipids / blood
Macrophages / metabolism
Middle Aged
Obesity / physiopathology
Overweight / physiopathology
Oxidative Stress / physiology
Postprandial Period*
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Lipids; 97C5T2UQ7J/Cholesterol

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