Document Detail


Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans.
MedLine Citation:
PMID:  17010953     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of short-term aerobic exercise and a following ramp incremental cycle ergometry to exhaustion on the acute response of the serum concentrations of brain derived neurotrophic factor (BDNF) and cortisol (COR) was examined in 8 healthy male athletes. Venous and capillary blood samples were drawn at rest, immediately after a 10 min warm-up period with aerobic exercise and after a ramp test to exhaustion, as well as 3, 6, 10 and 15 min post exercise. Capillary blood lactate (LA) concentration and blood gases as well as serum BDNF and COR concentrations did not change during the warm-up period. LA was increased (p<0.05) at the end of the ramp test and during recovery period while bicarbonate concentration, carbon dioxide pressure, pH and base excess were decreased (p<0.05) during this period. Serum BDNF was increased at the point of exhaustion (p<0.05) while no significant differences were found between values at rest and those during recovery period. At 10 and 15 min post incremental exercise, COR concentrations were increased (p<0.05) compared to rest. The present study is the first to demonstrate in humans that in contrast to short duration aerobic exercise immediately after a following short duration high-intensity exercise to exhaustion, there is a transient augmentation of serum BDNF concentration. Short-term response of serum BDNF and COR concentrations differs as BDNF returns to baseline level faster than COR.
Authors:
Sandra Rojas Vega; Heiko K Strüder; Bertha Vera Wahrmann; Annette Schmidt; Wilhelm Bloch; Wildor Hollmann
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Publication Detail:
Type:  Journal Article     Date:  2006-09-28
Journal Detail:
Title:  Brain research     Volume:  1121     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-14     Completed Date:  2007-02-12     Revised Date:  2007-09-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
Affiliation:
Institute of Motor Control and Movement Technique, German Sport University Cologne, Carl-Diem-Weg 6, 50933 Cologne, Germany. Rojas@dshs-koeln.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain-Derived Neurotrophic Factor / blood*
Exercise / physiology*
Exercise Test
Heat Exhaustion / blood*
Humans
Hydrocortisone / blood*
Lactic Acid / blood
Male
Sports
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 50-21-5/Lactic Acid; 50-23-7/Hydrocortisone
Comments/Corrections
Erratum In:
Brain Res. 2007 Jul 2;1156:174-5

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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