| Acute Aerobic Exercise in Humans Increases Cytokine Expression in CD27- but not CD27+ CD8+ T-CELLS. | |
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MedLine Citation:
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PMID: 23017234 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Exercise alters the percentage of CD8(+)T-cells in the bloodstream expressing type 1 and type II cytokines. It is unknown if this reflects a change in cytokine expression within individual cells, or whether these observations result from the exercise-induced shift in the proportions of early/intermediate (CD27(+)) and late (CD27(-)) differentiated cells, which have vastly different cytokine profiles. 16 males cycled for 60 min at 95% maximal steady state. Mononuclear cells isolated from blood collected before, immediately after, and 1h after exercise were cultured overnight with and without phytohaemagglutinin stimulation. CD8(+)T-cells were assessed for differentiation markers and intracellular cytokine expression by flow cytometry. The numbers and percentage of CD27(-)CD8(+)T-cells increased immediately after exercise and fell below pre-exercise values 1h later. At 1h after exercise, an increased number and percentage of CD8(+)T-cells expressing IL-2, IFN-γ, TNF-α, IL-6, IL-4, and IL-10 was observed in both stimulated and unstimulated cells. The cytokine response to exercise was confined to CD27(-)CD8(+)T-cells, although cytokine expression among CD8(+)T-cells was highest when the proportion of CD27(-)CD8(+)T-cells was lowest. Moreover, the cytokine response to exercise could be predicted by the number of late cells in resting blood: cytokine expression was highest among those with low resting proportions of late cells. We conclude that exercise-induced changes in the percentage of CD8(+)T-cells expressing cytokines are not due to proportional shifts in early/intermediate and late differentiated T-cells. Exercise may prime late-differentiated blood CD8(+)T-cells to initiate effector functions in preparation for their extravasation into the tissues. |
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Authors:
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Emily C Lavoy; Jos A Bosch; Thomas W Lowder; Richard J Simpson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-24 |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: - ISSN: 1090-2139 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, Houston, Texas, USA 77204. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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