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Acute Administration of Inorganic Nitrate Reduces VO2peakin EnduranceAthletes.
MedLine Citation:
PMID:  21407132     Owner:  NLM     Status:  Publisher    
PURPOSE:: Humans can reduce inorganic nitrate (NO3-) to nitrite (NO2-), nitric oxide (NO) and other bioactive nitrogen oxides. The purpose of this study was to test the hypothesis that a single dose of inorganic nitrate before exercise might enhance the tolerance of endurance athletes to high intensity exercise. METHODS:: Eleven cyclists (age: 34.3 ± 4.8 yrs; VO2peak: 65.1 ± 6.2 mL·kg·min) participated in this randomized, double-blind, crossover study. Subjects received dietary supplementation with nitrate (NaNO310 mg·kg of body mass) or a placebo (NaCl) three hours before exercise. They then performed a cycle ergometer test which consisted of four 6-min submaximal workloads, corresponding to 2.0, 2.5, 3.0 and 3.5 W·kg of body mass, interspersed with 3 min of passive recovery. After a 5-min recovery period, the subjects performed one incremental exercise test until exhaustion. RESULTS:: Plasma nitrate and nitrite were significantly higher (P< 0.05) three hours after supplementation (nitrate: 250 ± 80 μm; nitrite: 2,313 ± 157 nM) than after the placebo (nitrate: 29 ± 8 μm; nitrite: 1,998 ± 206 nM) at resting conditions. Nitrate supplementation significantly reduced VO2peak (nitrate:4.64 ± 0.35; placebo: 4.82 ± 0.33 L·min; P = 0.010) and the ratio between VO2/power at maximal intensity (nitrate: 11.2 ± 1.1; placebo: 11.8 ± 1.1 mL·min/W; P = 0.031). This reduction of VO2 occurred without changes in the time to exhaustion (nitrate:416 ± 32; placebo: 409 ± 27 seconds) or in the maximal power (nitrate:416 ± 29; placebo: 410 ± 28 W). CONCLUSION:: A single oral dose of inorganic nitrate acutely reduces VO2peak without compromising the maximal exercise performance.
Raúl Bescós; Ferran A Rodríguez; Xavier Iglesias; Miguel D Ferrer; Elena Iborra; Antoni Pons
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-10
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1National Institute of Physical Education INEFC-Barcelona.Research Group on Sport Sciences.University of Barcelona; 2 Laboratory of Physical Activity Science.Research Group on Community Nutrition and Oxidative Stress.University of Balearic Islands; 3 Angiology and Vascular Cirurgy. University Hospital of Bellvitge.
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