Document Detail

Acupuncture: a novel hypothesis for the involvement of purinergic signalling.
MedLine Citation:
PMID:  19628336     Owner:  NLM     Status:  MEDLINE    
The hypothesis is summarised schematically in Fig. 1. It is proposed that mechanical deformation of the skin by needles and application of heat or electrical current leads to release of large amounts of ATP from keratinocytes, fibroblasts and other cells in skin; the ATP then occupies specific receptor subtypes expressed on sensory nerve endings in the skin and tongue; the sensory nerves send impulses through ganglia to the spinal cord, the brain stem, hypothalamus and higher centres; the brain stem and hypothalamus contain neurons that control autonomic functions, including cardiovascular, gastrointestinal, respiratory, urinogenital and musculo-skeletal activity. Impulses generated in sensory fibres in the skin connect with interneurons to modulate (either inhibition or facilitation) the activities of the motoneurons in the brain stem and hypothalamus to change autonomic functions; specifically activated sensory nerves, via interneurons, also inhibit the neural pathways to the pain centres in the cortex.
Geoffrey Burnstock
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Publication Detail:
Type:  Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Medical hypotheses     Volume:  73     ISSN:  1532-2777     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-11-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-2     Citation Subset:  IM    
Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.
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MeSH Terms
Acupuncture Therapy*
Adenosine Triphosphate / metabolism*
Autonomic Nervous System / physiopathology
Brain / physiopathology*
Models, Neurological*
Pain / physiopathology*,  prevention & control*
Receptors, Purinergic / metabolism*
Signal Transduction*
Reg. No./Substance:
0/Receptors, Purinergic; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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