| Acupuncture in the treatment of heart failure. | |
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MedLine Citation:
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PMID: 15078586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Few clinical studies evaluating the efficacy of acupuncture in heart failure have been performed. These studies have focused on the acupoint Neiguan (P6) in patients experiencing heart failure and have variably reported either an acute increase in ventricular contractility and/or relaxation or no effect on ventricular contractility and/or relaxation. To date, clinical studies have been hampered by small enrollment, inadequate controls, and unblinded design. Recent scientific studies of animal models of acupuncture support the concept that acupuncture produces release of endogenous opioids in the central nervous system, which in turn could inhibit central sympathetic outflow. Patients experiencing heart failure have markedly elevated sympathetic activity, and those with the greatest sympathetic activation have the worst survival. Preliminary data from our laboratory suggests that acupuncture could be sympatholytic in heart failure. We found that sympathetic activation during acute mental stress was virtually eliminated after acupuncture. More studies defining the efficacy of acupuncture, and its mechanisms, in the treatment of heart failure are warranted. |
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Authors:
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Holly R Middlekauff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiology in review Volume: 12 ISSN: 1061-5377 ISO Abbreviation: Cardiol Rev Publication Date: 2004 May-Jun |
Date Detail:
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Created Date: 2004-04-13 Completed Date: 2004-07-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9304686 Medline TA: Cardiol Rev Country: United States |
Other Details:
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Languages: eng Pagination: 171-3 Citation Subset: IM |
Affiliation:
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University of California-Los Angeles School of Medicine, Division of Cardiology, Los Angeles, California 90095, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acupuncture Therapy
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methods* Heart Failure / physiopathology, therapy* Humans Sympathetic Nervous System / physiopathology Treatment Outcome |
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