Document Detail


Acupuncture in the prophylactic treatment of migraine without aura: a comparison with flunarizine.
MedLine Citation:
PMID:  12390610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: In a randomized controlled trial extending over 6 months, we evaluated the effectiveness of acupuncture versus flunarizine in the prophylactic treatment of migraine without aura. METHODS: One hundred sixty women with migraines were randomly assigned to acupuncture treatment (group A, n = 80) or to an oral therapy with flunarizine (group F, n = 80). In group A, acupuncture was carried out in weekly sessions for the first 2 months and then once a month for the next 4 months. The same acupoints were used at each treatment: LR3 Taichong, SP6 Sanyinjiao, ST36 Zusanli, CV12 Zhongwan, LI4 Hegu, PC6 Neiguan, GB20 Fengchi, GB14 Yangbai, EX-HN5 Taiyang, GV20 Baihui. In group F, 10 mg flunarizine were given daily for the first 2 months and then for 20 days per month for the next 4 months. RESULTS: The frequency of attacks and use of symptomatic drugs significantly decreased during treatment in both groups. The number of attacks after 2 and 4 months of therapy was significantly lower in group A than in group F, and analgesic consumption was significantly lower in group A at 2 months of treatment. At 6 months no such differences existed between the two treatment groups. Pain intensity was significantly reduced only by acupuncture treatment. Side effects were significantly less frequent in group A. CONCLUSIONS: Acupuncture proved to be adequate for migraine prophylaxis. Relative to flunarizine, acupuncture treatment exhibited greater effectiveness in the first months of therapy and superior tolerability.
Authors:
Gianni Allais; Cristina De Lorenzo; Piero E Quirico; Gisella Airola; Giampiero Tolardo; Ornella Mana; Chiara Benedetto
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Headache     Volume:  42     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-22     Completed Date:  2002-12-27     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-61     Citation Subset:  IM    
Affiliation:
Woman's Headache Center, Department of Gynecology and Obstetrics, University of Turin, Turin, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acupuncture Therapy* / methods
Adolescent
Adult
Female
Flunarizine / therapeutic use*
Humans
Middle Aged
Migraine without Aura / prevention & control*
Treatment Outcome
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 52468-60-7/Flunarizine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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