Document Detail


Acupuncture improves exercise tolerance of patients with heart failure: a placebo-controlled pilot study.
MedLine Citation:
PMID:  20554511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Congestive heart failure (CHF) is a complex clinical syndrome with autonomic dysbalance and increased plasma levels of inflammatory cytokines, which further worsen the syndrome. Experimental data have shown that stimulation of certain acupoints decreases autonomic dysbalance. OBJECTIVE: To test the therapeutic potential of acupuncture for life-threatening diseases such as CHF. METHODS: 17 stable patients with CHF (New York Heart Association class II-III, ejection fraction <40%) receiving optimised heart failure medication were randomised into a verum acupuncture (VA) and placebo acupuncture (PA) group. Cardiopulmonary function, heart rate variability and quality of life were explored. RESULTS: No improvements of the cardiac ejection fraction or peak oxygen uptake were observed, but the ambulated 6 min walk distance was remarkably increased in the VA group (+32+/-7 m) but not the PA group (-1+/-11 m; p<0.01). Accordingly, post-exercise recovery after maximal exercise and the VE/VCO(2) slope, a marker of ventilatory efficiency, were improved after VA but not PA. Furthermore, heart rate variability increased after VA, but decreased after PA. The 'general health' score and 'body pain' score of the quality-of-life questionnaire SF-36 tended to be improved after VA. CONCLUSION: Acupuncture may become an additional therapeutic strategy to improve the exercise tolerance of patients with CHF, potentially by improving skeletal muscle function.
Authors:
Arnt V Kristen; Boris Schuhmacher; Kathrin Strych; Dirk Lossnitzer; Hans-Christoph Friederich; Thomas Hilbel; Markus Haass; Hugo A Katus; Antonius Schneider; Konrad M Streitberger; Johannes Backs
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-15
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  1396-400     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acupuncture Therapy / methods*
Aged
Autonomic Nervous System / physiopathology
Cytokines / blood
Exercise Test / methods
Exercise Tolerance / physiology*
Female
Heart Failure / physiopathology,  therapy*
Heart Rate / physiology
Humans
Inflammation Mediators / blood
Male
Middle Aged
Prospective Studies
Quality of Life
Single-Blind Method
Treatment Outcome
Chemical
Reg. No./Substance:
0/Cytokines; 0/Inflammation Mediators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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