Document Detail


Acupuncture and exercise restore adipose tissue expression of sympathetic markers and improve ovarian morphology in rats with dihydrotestosterone-induced PCOS.
MedLine Citation:
PMID:  19158405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Altered activity of the sympathetic nervous system, which innervates adipose and ovarian tissue, may play a role in polycystic ovary syndrome (PCOS). We hypothesize that electro-acupuncture (EA) and physical exercise reduce sympathetic activity by stimulating ergoreceptors and somatic afferent pathways in muscles. Here we investigated the effects of low-frequency EA and physical exercise on mRNA expression of sympathetic markers in adipose tissue and on ovarian morphology in female rats that received dihydrotestosterone (DHT) continuously, starting before puberty, to induce PCOS. At age 11 wk, rats with DHT-induced PCOS were randomly divided into three groups: PCOS, PCOS plus EA, and PCOS plus exercise. The latter two groups received 2-Hz EA (evoking muscle twitches) three times/week or had free access to a running wheel for 4-5 wk. In mesenteric adipose tissue, expression of beta(3)-adrenergic receptor (ADRB3), nerve growth factor (NGF), and neuropeptide Y (NPY) mRNA was higher in untreated PCOS rats than in controls. Low-frequency EA and exercise downregulated mRNA expression of NGF and NPY, and EA also downregulated expression of ADRB3, compared with untreated rats with DHT-induced PCOS. EA and exercise improved ovarian morphology, as reflected in a higher proportion of healthy antral follicles and a thinner theca interna cell layer than in untreated PCOS rats. These findings support the theory that increased sympathetic activity contributes to the development and maintenance of PCOS and that the effects of EA and exercise may be mediated by modulation of sympathetic outflow to the adipose tissue and ovaries.
Authors:
Louise Mannerås; Stefan Cajander; Malin Lönn; Elisabet Stener-Victorin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-21
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  296     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-27     Completed Date:  2009-06-05     Revised Date:  2012-11-02    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R1124-31     Citation Subset:  IM    
Affiliation:
Department of Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Acupuncture Therapy
Adipose Tissue / innervation*,  metabolism
Animals
Dihydrotestosterone
Disease Models, Animal
Exercise Therapy*
Female
Gene Expression Regulation
Nerve Growth Factor / genetics
Neuropeptide Y / genetics
Ovary / innervation*,  pathology
Polycystic Ovary Syndrome / chemically induced,  genetics,  pathology,  therapy*
RNA, Messenger / metabolism
Rats
Rats, Wistar
Receptors, Adrenergic, beta-3 / genetics
Receptors, Androgen / genetics
Sympathetic Nervous System / metabolism*
Chemical
Reg. No./Substance:
0/Neuropeptide Y; 0/RNA, Messenger; 0/Receptors, Adrenergic, beta-3; 0/Receptors, Androgen; 521-18-6/Dihydrotestosterone; 9061-61-4/Nerve Growth Factor

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