| Acupuncture can improve absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. | |
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MedLine Citation:
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PMID: 19274704 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this research was to explore whether acupuncture could improve the absorption of baicalin from extracts of Scutellaria baicalensis Georgi in normal rats. Twenty male Sprague-Dawley (SD) rats were divided randomly into two groups. Group A was treated with a combination of oral administration of Scutellaria baicalensis Georgi extracts and acupuncture. Group B was treated only with oral administration of Scutellaria baicalensis Georgi extracts, in the same dosage as Group A. After treatment, the plasma concentration of baicalin was detected and pharmacokinetic analysis was conducted using high performance liquid chromatography (HPLC). The results showed that the plasma concentration of baicalin in Group A was significantly higher than in Group B, and that acupuncture at the acupoints Jizhong (Du6), Dazhui (Du14) and Zhongwan (Ren12) made the plasma concentration-time course of baicalin produce a bimodal phenomenon, increased the area under the curve (AUC) and slowed the elimination of baicalin, thus significantly improving the absorption of baicalin from extracts of Scutellaria baicalensis Georgi in rats. |
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Authors:
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Jue Zhou; Fan Qu; Elizabeth Burrows; Yongping Yu; Rui Nan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 23 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 1415-20 Citation Subset: IM |
Copyright Information:
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(c) 2009 John Wiley & Sons, Ltd. |
Affiliation:
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acupuncture Points Acupuncture Therapy* Animals Area Under Curve Flavonoids / administration & dosage, blood, pharmacokinetics* Intestinal Absorption Male Phytotherapy Plant Extracts / administration & dosage, blood, pharmacokinetics* Rats Rats, Sprague-Dawley Scutellaria baicalensis / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Plant Extracts; 21967-41-9/baicalin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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