Document Detail

Actual role of radiofrequency ablation of liver metastases.
MedLine Citation:
PMID:  17429644     Owner:  NLM     Status:  MEDLINE    
The liver is, second only to lymph nodes, the most common site for metastatic disease irrespective of the primary tumour. More than 50% of all patients with malignant diseases will develop liver metastases with a significant morbidity and mortality. Although the surgical resection leads to an improved survival in patients with colorectal metastases, only approximately 20% of patients are eligible for surgery. Thermal ablation and especially radiofrequency ablation emerge as an important additional therapy modality for the treatment of liver metastases. RF ablation shows a benefit in life expectancy and may lead in a selected patient group to cure. Percutaneous RF ablation appears safer (versus cryotherapy), easier (versus laser), and more effective (versus ethanol instillation and transarterial chemoembolisation) compared with other minimally invasive procedures. RF ablation can be performed by a percutaneous, laparoscopical or laparotomic approach, and may be potentially combined with chemotherapy and surgery. At present ideal candidates have tumours with a maximum diameter less than 3.5 cm. An untreatable primary tumour or a systemic disease represents contraindications for performing local therapies. Permanent technical improvements of thermal ablation devices and a better integration of thermal ablation in the overall patient care may lead to prognosis improvement in patients with liver metastases.
Philippe L Pereira
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Publication Detail:
Type:  Journal Article; Review     Date:  2007-02-15
Journal Detail:
Title:  European radiology     Volume:  17     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-10     Completed Date:  2007-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2062-70     Citation Subset:  IM    
Department of Diagnostic Radiology, Eberhard-Karls-University of Tübingen, Hoppe-Seyler-Str.3, 72076 Tuebingen, Germany.
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MeSH Terms
Catheter Ablation*
Liver Neoplasms / secondary*,  surgery*
Magnetic Resonance Imaging, Interventional
Patient Selection
Radiography, Interventional
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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