Document Detail

Actual Proliferating Index and p53 protein expression as prognostic marker in odontogenic cysts.
MedLine Citation:
PMID:  19563416     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this study was to evaluate the biological aggressiveness of odontogenic keratocyst/keratocystic odontogenic tumour (KCOT), radicular cyst (RC) and dentigerous cyst (DC) by observing the actual proliferative activity of epithelium, and p53 protein expression. METHODS: The actual proliferative activity was measured by Ki-67 Labelling Index and argyrophilic nucleolar organizing regions (AgNOR) count per nucleus. The p53 protein expression was also evaluated. RESULTS: Ki-67 positive cells were observed higher in suprabasal cell layers of KCOT with uniform distribution, a few of them were predominantly observed in basal cell layer in RC and DC. The AgNOR count was significantly higher in suprabasal cell layers of KCOT. The actual proliferative activity was noted to be higher in suprabasal cell layers of KCOT. The p53 immunolabelling was dense and scattered in basal and suprabasal cell layers in KCOT. The weakly stained p53 positive cells were observed diffusely distributed in KCOT, whereas they were mainly seen in basal cell layer of RC and DC. CONCLUSION: The quantitative and qualitative differences of the proliferative activity and the p53 protein expression in sporadic KCOT may be associated with intrinsic growth potential that could play a role in its development and explain locally aggressive biological behaviour. AgNOR count and p53 protein detection in odontogenic lesions can be of great consequence to predict the biological behaviour and prognosis.
A R Gadbail; M Chaudhary; S Patil; M Gawande
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Publication Detail:
Type:  Journal Article     Date:  2009-06-26
Journal Detail:
Title:  Oral diseases     Volume:  15     ISSN:  1601-0825     ISO Abbreviation:  Oral Dis     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-18     Completed Date:  2009-12-07     Revised Date:  2010-02-04    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  490-8     Citation Subset:  D    
Department of Oral and Maxillofacial Pathology & Microbiology, Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Medical Sciences, Sawangi (M), Wardha, Maharashtra 442001, India.
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MeSH Terms
Antigens, Nuclear / analysis
Basement Membrane / chemistry
Case-Control Studies
Cell Proliferation
Epithelial Cells / pathology
Ki-67 Antigen / analysis
Mouth Mucosa / chemistry,  metabolism,  pathology
Nuclear Proteins / analysis
Nucleolus Organizer Region
Odontogenic Cysts / chemistry,  metabolism*,  pathology*
Tumor Suppressor Protein p53 / analysis,  biosynthesis*
Reg. No./Substance:
0/Antigens, Nuclear; 0/Ki-67 Antigen; 0/Nuclear Proteins; 0/Tumor Suppressor Protein p53; 0/nucleolar organizer region associated proteins

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