| Activity of some 3-formylchromone derivatives on the induction of chloroplast-free mutants in Euglena gracilis. | |
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MedLine Citation:
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PMID: 10755227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hereditary bleaching test on Euglena gracilis was used for detecting extranuclear mutations. The highest bleaching activity (induction of the chloroplast-free mutants) was shown by the 6-R-3-formylchromones. On the other hand, bleaching-inactive 6-R-3-formylchromone acylhydrazones (derived from gallic and salicylic acids), added at sufficient concentrations in the case of chloroplast mutagenesis in E. gracilis, act as a potent antimutagen. This effect appeared to be a unique feature of chromone derivatives, but was dependent on the type of mutagen. These substances were very effective against the bleaching activity of acridine orange, and were less effective against N-methyl-N'-nitro-N-nitrosoguanidine. The genotoxic effects of these mutagens was reduced, especially during the first stages of induction of this specific cytoplasmic mutation. The experimental study of mutagenicity and antimutagenicty of 3-formylchromone hydrazones was reinforced by data obtained by the semi-empirical AM1 method and lipophilicity values. |
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Authors:
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P Foltínová; M Lácová; D Loos |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Farmaco (Società chimica italiana : 1989) Volume: 55 ISSN: 0014-827X ISO Abbreviation: Farmaco Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-06-08 Completed Date: 2000-06-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8912641 Medline TA: Farmaco Country: ITALY |
Other Details:
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Languages: eng Pagination: 21-6 Citation Subset: IM |
Affiliation:
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Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromones / chemistry, pharmacology* Euglena gracilis / drug effects*, genetics Methylnitronitrosoguanidine / toxicity Mutagenicity Tests Mutagens / toxicity Mutation* |
| Chemical | |
Reg. No./Substance:
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0/Chromones; 0/Mutagens; 70-25-7/Methylnitronitrosoguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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