Document Detail

Activity of some 3-formylchromone derivatives on the induction of chloroplast-free mutants in Euglena gracilis.
MedLine Citation:
PMID:  10755227     Owner:  NLM     Status:  MEDLINE    
The hereditary bleaching test on Euglena gracilis was used for detecting extranuclear mutations. The highest bleaching activity (induction of the chloroplast-free mutants) was shown by the 6-R-3-formylchromones. On the other hand, bleaching-inactive 6-R-3-formylchromone acylhydrazones (derived from gallic and salicylic acids), added at sufficient concentrations in the case of chloroplast mutagenesis in E. gracilis, act as a potent antimutagen. This effect appeared to be a unique feature of chromone derivatives, but was dependent on the type of mutagen. These substances were very effective against the bleaching activity of acridine orange, and were less effective against N-methyl-N'-nitro-N-nitrosoguanidine. The genotoxic effects of these mutagens was reduced, especially during the first stages of induction of this specific cytoplasmic mutation. The experimental study of mutagenicity and antimutagenicty of 3-formylchromone hydrazones was reinforced by data obtained by the semi-empirical AM1 method and lipophilicity values.
P Foltínová; M Lácová; D Loos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Farmaco (Società chimica italiana : 1989)     Volume:  55     ISSN:  0014-827X     ISO Abbreviation:  Farmaco     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-06-08     Completed Date:  2000-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912641     Medline TA:  Farmaco     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
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MeSH Terms
Chromones / chemistry,  pharmacology*
Euglena gracilis / drug effects*,  genetics
Methylnitronitrosoguanidine / toxicity
Mutagenicity Tests
Mutagens / toxicity
Reg. No./Substance:
0/Chromones; 0/Mutagens; 70-25-7/Methylnitronitrosoguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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