| Activity of serum lipase [EC 3.1.1.3] and the diversity of serum lipid profile in psoriasis. | |
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MedLine Citation:
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PMID: 11782673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In the course of psoriasis the loss of scales from the skin surface is observed. This may be related to lipid disorders in epidermis and in blood serum. The aim of the study was to find out if serum lipid profile disturbances occur in psoriatic patients. MATERIAL/METHODS: We studied 26 male and 15 female normolipidemic psoriatic patients, and 29 male and 28 female healthy normolipidemic volunteers. The concentrations of serum pancreatic lipase, total cholesterol, HDL cholesterol, LDL cholesterol, total phospholipids, HDL phospholipids, LDL phospholipids and triglycerides were measured with enzymatic methods. RESULTS: The study of male patients demonstrated a statistically significant decrease in HDL cholesterol concentration and statistically significant increase in triglyceride concentration. In psoriatic females, we observed a statistically significant decrease in HDL cholesterol concentration, a statistically significant decrease in HDL phospholipid concentration, and a statistically significant increase in pancreatic lipase concentration. In addition, the pancreatic lipase concentration increased insignificantly in the male group. We found lipid profile disturbances in the groups of psoriatic patients, in comparison with the age-, sex-, and BMI-matched control groups. CONCLUSIONS: The obtained results suggest the necessity of careful administration of medicines to psoriatic patients suffering from systemic diseases and treated with drugs affecting lipid metabolism. |
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Authors:
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Aldona Pietrzak; Barbara Lecewicz-Toruń |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 8 ISSN: 1234-1010 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2002 Jan |
Date Detail:
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Created Date: 2002-01-09 Completed Date: 2002-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR9-CR13 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Medical University of Lublin, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cholesterol / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Female Humans Lipase / blood* Lipids / blood* Male Middle Aged Pancreas / enzymology Phospholipids / blood Psoriasis / blood* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipids; 0/Phospholipids; 0/Triglycerides; 57-88-5/Cholesterol; EC 3.1.1.3/Lipase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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