Document Detail

Activity of rheumatoid arthritis and urinary pyridinoline and deoxypyridinoline.
MedLine Citation:
PMID:  10982689     Owner:  NLM     Status:  MEDLINE    
The aims of this study were to examine levels of the crosslinking components of collagen, pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) which are bone resorption markers, in patients with rheumatoid arthritis (RA), and to determine their association with disease activity and bone mineral density (BMD). These bone resorption markers were measured in 35 postmenopausal women with RA, 30 age-matched female patients with osteoarthritis of the knee (controls), and 47 patients with bone fracture. The mean BMD in the RA patients was lower than that in the control group, and the Z-score (number of standard deviations above and below the normal mean after comparison with age and sex matched normal control values) was significantly lower. Mean levels of Pyr and D-Pyr were significantly higher in the RA patients than in the control group, and the Pyr/D-Pyr ratio was also higher in the RA patients than in the other groups. Regarding the relationship between the bone resorption markers and RA activity, Pyr increased as the Lansbury's joint score (number of swollen joints corrected for joint size according Lansbury) rose, showing a normal correlation; D-Pyr also showed a normal correlation. Pyr and D-Pyr were high in patients with a high erythrocyte sedimentation rate, showing a normal correlation. Only Pyr increased with increases in C-reactive protein (CRP), showing a normal correlation. These findings suggested that a high value for Pyr (which includes a large amount of collagen type II) indicated that RA activity was affected more by synovitis, rather than by systemic osteoporosis.
O Kameyama; Y Nakahigashi; H Nakao; D Uejima; H Tsuji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association     Volume:  5     ISSN:  0949-2658     ISO Abbreviation:  J Orthop Sci     Publication Date:  2000  
Date Detail:
Created Date:  2000-11-03     Completed Date:  2000-11-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9604934     Medline TA:  J Orthop Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Department of Orthopaedic Surgery, Kansai Medical University Rakusai New Town Hospital, 3-6 Higashi Shinbayashi, Nishigyo, Kyoto, 610-1142, Japan.
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MeSH Terms
Absorptiometry, Photon
Aged, 80 and over
Amino Acids / urine*
Arthritis, Rheumatoid / diagnosis*,  urine
Bone Density / physiology
Bone Resorption / diagnosis,  urine
Chromatography, High Pressure Liquid
Middle Aged
Reference Values
Reg. No./Substance:
0/Amino Acids; 63800-01-1/pyridinoline; 90032-33-0/deoxypyridinoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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