| Activity of the renin-angiotensin-aldosterone and sympathetic nervous system and their relation to hemodynamic and clinical abnormalities in infants with left-to-right shunts. | |
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MedLine Citation:
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PMID: 11376824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied neurohormonal, clinical and invasively measured hemodynamic data of 47 infants with left-to-right shunts and varying degrees of congestive failure. When referred to a clinical heart failure score, plasma renin activities (r=0.71) and norepinephrine levels (r=0.43) are significantly increased. Arterial hypotension seems to be the hemodynamic trigger of renin release (r=-0.72), but not decreased systemic cardiac index (r=-0.43), the magnitude of the left-to-right shunt (r=0.33) or a reduced ejection fraction (r=0.12). These data indicate neurohormonal activation in infants with left-to-right shunts with preserved myocardial function is similar to the activation in adults with heart failure secondary to myocardial pump failure. These findings have to be considered for optimal medical treatment of these infants with angiotensin-converting enzyme inhibitors or beta-blockers. |
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Authors:
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R Buchhorn; R D Ross; D Bartmus; A Wessel; M Hulpke-Wette; J Bürsch |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cardiology Volume: 78 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-29 Completed Date: 2001-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Ireland |
Other Details:
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Languages: eng Pagination: 225-30; discussion 230-1 Citation Subset: IM |
Affiliation:
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Department of Pediatric Cardiology, Georg-August-University, Robert-Koch-Strasse 40, 37075, Göttingen, Germany. rbuchho@gwdg.de16 |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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blood Cardiac Output, Low / blood, etiology, physiopathology Heart Defects, Congenital / physiopathology* Heart Failure / blood, etiology*, physiopathology Hemodynamics* Humans Infant Norepinephrine / blood Renin / blood Renin-Angiotensin System* Statistics, Nonparametric Sympathetic Nervous System / physiopathology* |
| Chemical | |
Reg. No./Substance:
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51-41-2/Norepinephrine; 52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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