Document Detail

Activity of rapidly-adapting receptors to histamine and antigen challenge before and after sodium cromoglycate.
MedLine Citation:
PMID:  3923960     Owner:  NLM     Status:  MEDLINE    
Sodium cromoglycate (SCG) blocks histamine release from sensitized mast cells challenged by antigen in vitro. Yet, not all the observed effects of SCG in vivo can be explained by this mechanism alone. Rapidly-adapting or "irritant" receptors (RAR) are thought to mediate reflex bronchoconstriction. Others have proposed that SCG may desensitize these receptors to histamine. We administered aerosols of histamine (100 micrograms/ml given for 3 min) before and after SCG (20 mg/ml aerosol for 5 min) to adult, mongrel dogs. SCG did not reduce the increase in tracheal pressure or RAR activity in response to histamine challenge. We also administered aerosols of Ascaris suum antigen (7 min) to dogs which had shown a positive skin reaction to subepidermal injection of this antigen. SCG attenuated both the increase in tracheal pressure and RAR nerve activity in response to the antigen challenge. These findings suggest that SCG does not affect the activity of the RAR or decrease the tracheal pressure in response to histamine challenge in an anesthetized dog, whereas SCG is effective in decreasing the response of both these parameters to antigen challenge when given prophylactically presumably by stabilizing the mast cell membrane.
D R Bergren; D L Myers; M Mohrman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives internationales de pharmacodynamie et de thérapie     Volume:  273     ISSN:  0003-9780     ISO Abbreviation:  Arch Int Pharmacodyn Ther     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-07-12     Completed Date:  1985-07-12     Revised Date:  2012-01-12    
Medline Journal Info:
Nlm Unique ID:  0405353     Medline TA:  Arch Int Pharmacodyn Ther     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  88-99     Citation Subset:  IM    
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MeSH Terms
Adaptation, Biological
Airway Resistance / drug effects
Antigens, Helminth
Ascaris / immunology
Cromolyn Sodium / pharmacology*
Respiratory Physiological Phenomena
Respiratory System / drug effects*
Trachea / drug effects
Vagus Nerve / physiology
Reg. No./Substance:
0/Antigens; 0/Antigens, Helminth; 15826-37-6/Cromolyn Sodium

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