| Activity profile of glycolamide ester prodrugs of ibuprofen. | |
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MedLine Citation:
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PMID: 11247537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of anti-inflammatory and analgesic activity but did not exhibit reduction in the ulcerogenicity on oral administration. However, all three exhibited significantly better topical activity in carrageenan-induced rat paw edema assay. In the same assay, they provided significant protection against inflammation when applied at a site remote to the inflammation site. |
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Authors:
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A K Bansal; R K Khar; R Dubey; A K Sharma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Drug development and industrial pharmacy Volume: 27 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-05-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: United States |
Other Details:
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Languages: eng Pagination: 63-70 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Pushp Vihar Sector 3, New Delhi 110 017, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry, pharmacology*, toxicity Carrageenan / administration & dosage Edema / chemically induced, drug therapy Esters Glycolates Humans Ibuprofen / analogs & derivatives, chemistry, pharmacology*, toxicity Inflammation Male Prodrugs* Rats Rats, Wistar Stomach Ulcer / chemically induced*, prevention & control |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Esters; 0/Glycolates; 0/Prodrugs; 15687-27-1/Ibuprofen; 598-42-5/glycolamide; 9000-07-1/Carrageenan |
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