Document Detail

Activity profile of glycolamide ester prodrugs of ibuprofen.
MedLine Citation:
PMID:  11247537     Owner:  NLM     Status:  MEDLINE    
Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of anti-inflammatory and analgesic activity but did not exhibit reduction in the ulcerogenicity on oral administration. However, all three exhibited significantly better topical activity in carrageenan-induced rat paw edema assay. In the same assay, they provided significant protection against inflammation when applied at a site remote to the inflammation site.
A K Bansal; R K Khar; R Dubey; A K Sharma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  27     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
College of Pharmacy, Pushp Vihar Sector 3, New Delhi 110 017, India.
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MeSH Terms
Administration, Oral
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  pharmacology*,  toxicity
Carrageenan / administration & dosage
Edema / chemically induced,  drug therapy
Ibuprofen / analogs & derivatives,  chemistry,  pharmacology*,  toxicity
Rats, Wistar
Stomach Ulcer / chemically induced*,  prevention & control
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Esters; 0/Glycolates; 0/Prodrugs; 15687-27-1/Ibuprofen; 598-42-5/glycolamide; 9000-07-1/Carrageenan

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