Document Detail


Activity profile of glycolamide ester prodrugs of ibuprofen.
MedLine Citation:
PMID:  11247537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycolamide esters of ibuprofen (I), namely, unsubstituted (II), N,N dimethyl (III), and N,N diethyl (IV), were synthesized and studied for different physicochemical, pharmacological, and toxicological properties. They were comparable with I in respect of anti-inflammatory and analgesic activity but did not exhibit reduction in the ulcerogenicity on oral administration. However, all three exhibited significantly better topical activity in carrageenan-induced rat paw edema assay. In the same assay, they provided significant protection against inflammation when applied at a site remote to the inflammation site.
Authors:
A K Bansal; R K Khar; R Dubey; A K Sharma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  27     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Pushp Vihar Sector 3, New Delhi 110 017, India.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  pharmacology*,  toxicity
Carrageenan / administration & dosage
Edema / chemically induced,  drug therapy
Esters
Glycolates
Humans
Ibuprofen / analogs & derivatives,  chemistry,  pharmacology*,  toxicity
Inflammation
Male
Prodrugs*
Rats
Rats, Wistar
Stomach Ulcer / chemically induced*,  prevention & control
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Esters; 0/Glycolates; 0/Prodrugs; 15687-27-1/Ibuprofen; 598-42-5/glycolamide; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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