| Activity of melatonin and other pineal indoles on the in vitro synthesis of cortisol, cortisone, and adrenal androgens. | |
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MedLine Citation:
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PMID: 2732894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vitro effects of 13 indole compounds on the synthesis of glucocorticoids and of adrenal androgens in sheep adrenal glands has been studied from 11-deoxycortisol as a precursor. This work demonstrates the activating effect of some indole compounds on 11 beta-hydroxylase and 17,20-desmolase and the inhibitory effect of most of them on 11 beta-hydroxysteroid dehydrogenase. Three categories could be distinguished: 1) compounds without any effect (5-hydroxytryptophan, 5-hydroxytryptamine); 2) compounds moderately increasing (10-30% as compared with controls) cortisol yields (tryptamine, melatonin, 6-hydroxymelatonin, 5-methoxytryptophol, indomethacin); and 3) compounds markedly increasing (80-100%) cortisol yields (5-methoxyindole acetic acid, 5-hydroxyindole acetic acid, 2-methylindole, 5-hydroxytryptophol, N-acetyl-5-hydroxytryptamine). In fact, since most of the studied indoles reduced 11 beta-hydroxysteroid dehydrogenase activity, the actual activation of cortisol synthesis was four to five times less. Lastly, all the studied compounds, but melatonin, increased the activity of 17,20 desmolase as seen from 11 beta-hydroxyandrostenedione and 11-ketoandrostenedione yields. The possible in vivo effects of the indoles for therapeutic use needs further studying. |
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Authors:
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Y Touitou; A Bogdan; A Auzéby; C Touitou |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of pineal research Volume: 6 ISSN: 0742-3098 ISO Abbreviation: J. Pineal Res. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-07-27 Completed Date: 1989-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 341-50 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculté de Médecine Pitié-Salpêtrière, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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metabolism Androgens / biosynthesis* Animals Cortisone / biosynthesis* Glucocorticoids / biosynthesis Hydrocortisone / biosynthesis* Indoles / pharmacology* Melatonin / pharmacology* Pineal Gland / anatomy & histology Sheep |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 0/Glucocorticoids; 0/Indoles; 50-23-7/Hydrocortisone; 53-06-5/Cortisone; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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