| Activity of matrix metalloproteinase-2 and -9 in abdominal aortic aneurysms. Relation to size and rupture. | |
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MedLine Citation:
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PMID: 11112465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: to investigate the activity of matrix metalloproteinase (MMP)-2 and -9 in asymptomatic abdominal aortic aneurysms (aAAAs) and ruptured abdominal aortic aneurysms (rAAAs). DESIGN: cross-sectional study. MATERIALS AND METHODS: MMP-2 and MMP-9 activity was estimated in biopsies from the anterior wall of 60 AAAs using gelatin zymography. There were 20 medium-sized (diameter 5<7 cm) aAAAs, 20 large (>57 cm) aAAAs and 20 rAAAs. MMP activity was quantified using a laser densitometer and expressed as arbitrary units (au). RESULTS: mean (SEM) MMP-9 activity was significantly lower in large aAAAs (1190 au +/-247) than in rAAAs (2647 au +/-498, p<0.05). There was no difference in MMP-2 activity. CONCLUSION: High MMP-9 activity in the AAA wall is associated with rupture. |
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Authors:
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E Petersen; A Gineitis; F Wågberg; K A Angquist |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery Volume: 20 ISSN: 1078-5884 ISO Abbreviation: Eur J Vasc Endovasc Surg Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2001-02-09 Completed Date: 2001-02-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9512728 Medline TA: Eur J Vasc Endovasc Surg Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 457-61 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Harcourt Publishers Ltd. |
Affiliation:
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Department of Surgery, Umeå University Hospital, Umeå, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aortic Aneurysm, Abdominal / enzymology*, pathology Aortic Rupture / enzymology* Cross-Sectional Studies Female Humans Male Matrix Metalloproteinase 2 / metabolism* Matrix Metalloproteinase 9 / metabolism* Middle Aged |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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