Document Detail


Activity of an injectable, sustained-release formulation of moxidectin administered prophylactically to mixed-breed dogs to prevent infection with Dirofilaria immitis.
MedLine Citation:
PMID:  11703014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To test the ability of a single injection of a sustained-release formulation of moxidectin (moxidectin SR) to protect dogs against heartworm infection for 180 days after inoculation with infective third-stage larvae (L3) of Dirofilaria immitis. ANIMALS: 32 adult mixed-breed dogs. PROCEDURE: Dogs were allocated to 4 groups on the basis of weight and sex. Dogs were injected SC with saline (0.9% NaCl) solution or moxidectin SR at the rate of 0.06, 0.17, or 0.5 mg/kg of body weight (day 0). Each dog was inoculated SC with 50 D immitis L3 180 days later. On days 330 and 331, dogs were euthanatized. The heart, lungs, and thoracic cavity were examined, and number and sex of heartworms were determined. RESULTS: A mean of 35.9 heartworms was recovered from untreated control dogs. Fourteen worms were recovered from 1 of 8 dogs given moxidectin SR at the lowest dosage, and none of the dogs in the 2 highest moxidectin treatment groups were infected. Small barely palpable granulomas were detected at injection sites of moxidectin-treated dogs. Frequency and size of granulomas were positively correlated with dose of moxidectin administered. CONCLUSIONS AND CLINICAL RELEVANCE: A single dose of moxidectin SR at a dosage as low as 0.17 mg/kg can safely and reliably confer complete protection against infection after challenge-exposure with D. immitis L3, and protection lasts for at least 180 days. This mode of prophylactic treatment against infection with heartworms effectively eliminates failure of prophylaxis that results from erratic administration of medications designed for monthly administration.
Authors:
J B Lok; D H Knight; G T Wang; M E Doscher; T J Nolan; M J Hendrick; W Steber; K Heaney
Related Documents :
21496454 - Effect of pregnane x receptor (pxr) prototype agonists on chemoprotective and drug meta...
21315654 - Preladenant in patients with parkinson's disease and motor fluctuations: a phase 2, dou...
23302034 - Cinnabar is different from mercuric chloride in mercury absorption and influence on the...
24223584 - Neuroprotective properties of a novel non-thiazoledinedione partial ppar- γ agonist ag...
15339864 - Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondria...
3243184 - Oral toxicology studies with xylene isomers and mixed xylenes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  62     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1721-6     Citation Subset:  IM    
Affiliation:
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / administration & dosage*,  blood,  pharmacokinetics
Delayed-Action Preparations
Dirofilaria immitis*
Dirofilariasis / parasitology,  prevention & control*
Dog Diseases / prevention & control*
Dogs
Female
Granuloma / pathology,  veterinary
Heart / parasitology
Histocytochemistry / veterinary
Injections, Subcutaneous / veterinary
Lung / parasitology
Macrolides
Male
Microspheres
Random Allocation
Skin / pathology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Delayed-Action Preparations; 0/Macrolides; 51570-36-6/milbemycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reliability of three bulk-tank antimicrobial residue detection assays used to test individual milk s...
Next Document:  Effects of nitrous oxide on mask induction of anesthesia with sevoflurane or isoflurane in dogs.