| Activity of homocarnosine and other compounds against staphylococcal infections in mice. | |
| | |
MedLine Citation:
|
PMID: 5684199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Homocarnosine and carnosine have been identified in bovine brain extracts which are effective in protecting mice against infections by Staphylococcus aureus. These peptides, as well as l-1-methylhistidine, beta-alanine, gamma-aminobutyric acid, delta-aminovaleric acid, epsilon-aminocaproic acid, 1-aminomethylcyclohexane-4-carboxylic acid, and anserine, were tested as prophylactic agents against S. aureus infections in C3H and Swiss mice. Histidine and methylhistidine were ineffective in preventing mortality in both mouse strains. Carnosine, anserine, and epsilon-aminocaproic acid were effective in C3H but not in Swiss mice. beta-Alanine and gamma-aminobutyric acid were weakly effective (C3H) or ineffective (Swiss). delta-Aminovaleric and 1-aminomethylcyclohexane-4-carboxylic acid (tested only in Swiss) were somewhat effective in early stages of the infection. Homocarnosine was the best compound and was highly effective in protecting both mouse strains against S. aureus infections by the testing procedure employed. |
| | |
Authors:
|
K Tanaka; Y Tsuchiya; N J Berberich; A J Mukkada; L G Nutini; E S Cook |
Related Documents
:
|
113249 - Changes in free amino acid level due to physical and chemical agents in ageing drosophila. 20005099 - Fluorinated piperidine acetic acids as gamma-secretase modulators. 3965619 - Rate equations and kinetics of uptake of alpha-aminoisobutyric acid and gamma-aminobuty... 9504989 - Sasp (small, acid-soluble spore proteins) and spore properties in bacillus thuringiensi... 11429859 - Efficient intramolecular asymmetric reductions of alpha-, beta-, and gamma-keto acids w... 2271949 - Distribution of gaba-like immunoreactivity in guinea pig vestibular cristae ampullaris. 11575789 - Nonaqueous catalytic fluorometric trace determination of vanadium based on the pyronine... 270279 - A new parallel plate dialyser. iii. preliminary experience on clinical performance. 7142509 - Pulmonary edema: a ct study of regional changes in lung density following oleic acid in... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Applied microbiology Volume: 16 ISSN: 0003-6919 ISO Abbreviation: Appl Microbiol Publication Date: 1968 Oct |
Date Detail:
|
Created Date: 1968-12-08 Completed Date: 1968-12-08 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7605802 Medline TA: Appl Microbiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1457-9 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alanine
/
therapeutic use Amino Acids / therapeutic use* Aminobutyric Acids / therapeutic use Aminocaproic Acids / therapeutic use Animals Brain Dipeptides / therapeutic use* Female Histidine / therapeutic use Mice Staphylococcal Infections / drug therapy* Tissue Extracts / therapeutic use Valerates / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids; 0/Aminobutyric Acids; 0/Aminocaproic Acids; 0/Dipeptides; 0/Tissue Extracts; 0/Valerates; 56-41-7/Alanine; 71-00-1/Histidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mortality of altitude-exposed mice infected with Pasteurella tularensis.
Next Document: Evaluation of a commercial air filter for removal of viruses from the air.