Document Detail


Activity of homocarnosine and other compounds against staphylococcal infections in mice.
MedLine Citation:
PMID:  5684199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Homocarnosine and carnosine have been identified in bovine brain extracts which are effective in protecting mice against infections by Staphylococcus aureus. These peptides, as well as l-1-methylhistidine, beta-alanine, gamma-aminobutyric acid, delta-aminovaleric acid, epsilon-aminocaproic acid, 1-aminomethylcyclohexane-4-carboxylic acid, and anserine, were tested as prophylactic agents against S. aureus infections in C3H and Swiss mice. Histidine and methylhistidine were ineffective in preventing mortality in both mouse strains. Carnosine, anserine, and epsilon-aminocaproic acid were effective in C3H but not in Swiss mice. beta-Alanine and gamma-aminobutyric acid were weakly effective (C3H) or ineffective (Swiss). delta-Aminovaleric and 1-aminomethylcyclohexane-4-carboxylic acid (tested only in Swiss) were somewhat effective in early stages of the infection. Homocarnosine was the best compound and was highly effective in protecting both mouse strains against S. aureus infections by the testing procedure employed.
Authors:
K Tanaka; Y Tsuchiya; N J Berberich; A J Mukkada; L G Nutini; E S Cook
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied microbiology     Volume:  16     ISSN:  0003-6919     ISO Abbreviation:  Appl Microbiol     Publication Date:  1968 Oct 
Date Detail:
Created Date:  1968-12-08     Completed Date:  1968-12-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7605802     Medline TA:  Appl Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1457-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alanine / therapeutic use
Amino Acids / therapeutic use*
Aminobutyric Acids / therapeutic use
Aminocaproic Acids / therapeutic use
Animals
Brain
Dipeptides / therapeutic use*
Female
Histidine / therapeutic use
Mice
Staphylococcal Infections / drug therapy*
Tissue Extracts / therapeutic use
Valerates / therapeutic use
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Aminobutyric Acids; 0/Aminocaproic Acids; 0/Dipeptides; 0/Tissue Extracts; 0/Valerates; 56-41-7/Alanine; 71-00-1/Histidine
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