| Activity of hepatic enzymes from week sixteen of pregnancy. | |
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MedLine Citation:
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PMID: 16325605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to determine the prevalence, epidemiology, and mother-child repercussions of increased alanine-aminotransferase levels from week 16 of pregnancy. STUDY DESIGN: A longitudinal observational study of 381 pregnant women. The cause of increased alanine-aminotransferase levels during pregnancy and repercussions on the neonate were studied in 283 cases. Statistical analysis was performed with Mann-Whitney test, chi2 test, or the Fisher exact test. RESULTS: The mean age of the mothers was 29.9 +/- 4.8 years. Twenty-five percent presented increased gamma-glutamyl-transpeptidase, alkaline phophatase, and dehydrogenase lactate from week 32. Increased alanine-aminotransferase was observed in 7.4% (95% CI, 5.00%-10.57%) of cases. Clinical disorders were light, transitory, and with no apparent cause, except for 1 hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, 3 preeclampsias, and 1 gravidic cholestasis. No statistically significant differences were observed in the group of mother-child with alanine-aminotransferase normal or increased. CONCLUSION: Most increases in alanine-aminotransferase from week 16 of pregnancy are transitory, non-specific, and have no repercussions on mother or child. |
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Authors:
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Angeles Ruiz-Extremera; Mar?a A L?pez-Garrido; Enriqueta Barranco; Mar?a D Quintero; Esther Ocete-Hita; Paloma Mu?oz de Rueda; Ana Gila; Javier Salmer?n |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 193 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-12-05 Completed Date: 2006-03-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 2010-6 Citation Subset: AIM; IM |
Affiliation:
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Pediatrics Service, H. Universitario San Cecilio, Granada, Spain. arextrem@ugr.es |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Alanine Transaminase / blood* Female Gestational Age Humans Infant, Newborn L-Lactate Dehydrogenase / blood Liver / enzymology* Pregnancy / blood* Pregnancy Outcome* Pregnancy Trimester, Second Pregnancy Trimester, Third Prospective Studies Socioeconomic Factors gamma-Glutamyltransferase / blood |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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