Document Detail


Activity of grepafloxacin and other fluoroquinones and newer macrolides against recent clinical isolates of Chlamydia pneumoniae.
MedLine Citation:
PMID:  10418764     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chlamydia pneumoniae is a frequent cause of community-acquired respiratory tract infection including pneumonia and bronchitis. Quinolones have attracted interest as potential therapy for community-acquired respiratory tract infections because they are active against a wide range of pathogens including C. pneumoniae and Mycoplasma pneumoniae. The in vitro susceptibilities of C. pneumoniae were determined for grepafloxacin, levofloxacin, moxifloxacin, trovafloxacin, clarithromycin and azithromycin. Isolates of C. pneumoniae tested included two reference strains, TW-183 and CM-1, and 12 recent clinical isolates from adults with community-acquired pneumonia. Susceptibility testing was performed in HEp-2 cells grown in 96-well microtiter plates. The MIC was the lowest antibiotic concentration at which no inclusions were seen. The MBC was the lowest concentration which resulted in no inclusions after passage in antibiotic-free medium. Grepafloxacin was the most active quinolone tested with an MIC50 of 0.125 mg/l, MIC90 and MBC90 of 0.5 mg/l. Grepafloxacin may have a role in the treatment of C. pneumoniae infections, but prospective clinical studies utilizing culture are lacking.
Authors:
P M Roblin; A Kutlin; T Reznik; M R Hammerschlag
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of antimicrobial agents     Volume:  12     ISSN:  0924-8579     ISO Abbreviation:  Int. J. Antimicrob. Agents     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-02     Completed Date:  1999-09-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111860     Medline TA:  Int J Antimicrob Agents     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, State University of New York, Health Science Center at Brooklyn, 11203-2098, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Infective Agents / pharmacology*
Cell Line
Chlamydophila pneumoniae / drug effects*
Fluoroquinolones*
Humans
Microbial Sensitivity Tests
Piperazines / pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Fluoroquinolones; 0/Piperazines; 119914-60-2/grepafloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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