Document Detail


Activity-dependent secretion of alpha-synuclein by enteric neurons.
MedLine Citation:
PMID:  23278133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is growing evidence supporting a role of extracellular alpha-synuclein in the spreading of Parkinson's disease (PD) pathology. Recent pathological studies have raised the possibility that the enteric nervous system (ENS) is one of the initial sites of alpha-synuclein pathology in PD. We therefore undertook this survey to determine whether alpha-synuclein can be secreted by enteric neurons. Alpha-synuclein secretion was assessed by immunoblot analysis of the culture medium from primary culture of ENS. We show that alpha-synuclein is physiologically secreted by enteric neurons via a conventional, endoplasmic reticulum/Golgi-dependent exocytosis, in a neuronal activity-regulated manner. Our study is the first to evidence that enteric neurons are capable of secreting alpha-synuclein, thereby providing new insights into the role of the ENS in the pathophysiology of PD.
Authors:
Sébastien Paillusson; Thomas Clairembault; Mandy Biraud; Michel Neunlist; Pascal Derkinderen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-15
Journal Detail:
Title:  Journal of neurochemistry     Volume:  125     ISSN:  1471-4159     ISO Abbreviation:  J. Neurochem.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-25     Completed Date:  2013-07-01     Revised Date:  2013-10-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  IM    
Copyright Information:
© 2012 International Society for Neurochemistry.
Affiliation:
Inserm, U913, Nantes, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Western
Brefeldin A / pharmacology
Enteric Nervous System / cytology,  secretion*
Exocytosis / physiology
Forskolin / pharmacology
Intestine, Small / innervation*
Neurons / cytology,  drug effects,  secretion*
Parkinson Disease / metabolism*,  pathology,  physiopathology
Primary Cell Culture
Protein Synthesis Inhibitors / pharmacology
Rats
alpha-Synuclein / secretion*
Chemical
Reg. No./Substance:
0/Protein Synthesis Inhibitors; 0/Snca protein, rat; 0/alpha-Synuclein; 20350-15-6/Brefeldin A; 66428-89-5/Forskolin
Comments/Corrections
Comment In:
J Neurochem. 2013 May;125(4):487-90   [PMID:  23448303 ]
Mov Disord. 2013 Aug;28(9):1209   [PMID:  23939718 ]

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