Document Detail


Activity-dependent regulation of myelin maintenance in the adult rat.
MedLine Citation:
PMID:  19041295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hindlimb unloading (HU) is known to induce changes in the neuromuscular system. However, no data describing the effects of HU on morphological characteristics of peripheral nerve have been reported so far. Therefore, we used soleus and radial nerves obtained from control and rats submitted to 14 days of HU to study the consequences of a decrease (soleus) or an increase (radial) in neural activity on its morphology. The mean number of fibers was not changed after HU. The soleus nerve axon diameter was weakly affected after HU, whereas the myelin thickness was reduced. For the radial nerve, both axon and fiber diameter were increased, and the myelin thickness and internodal distance were higher in HU rats. These results suggest that regulation of myelin maintenance undergoes plastic mechanisms. Neural activity and/or neural pattern might be essential in the maintenance of myelin sheath in adults.
Authors:
Marie-Hélène Canu; Michèle Carnaud; Florence Picquet; Laurence Goutebroze
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-13
Journal Detail:
Title:  Brain research     Volume:  1252     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Affiliation:
Laboratoire de Plasticité Neuromusculaire, EA 4345, IFR 147, Université des Sciences et Technologies de Lille, 59655 Villeneuve d'Ascq cedex, France. marie-helene.canu@univ-lille1.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology,  ultrastructure
Hindlimb Suspension / physiology
Male
Microscopy, Fluorescence
Motor Activity / physiology*
Myelin Sheath / physiology,  ultrastructure
Nerve Fibers, Myelinated / physiology*,  ultrastructure
Neural Conduction
Neuronal Plasticity
Peripheral Nerves / physiology*,  ultrastructure
Radial Nerve / physiology,  ultrastructure
Ranvier's Nodes / physiology,  ultrastructure
Rats
Rats, Wistar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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