| Activity-dependent neuroprotective protein: from gene to drug candidate. | |
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MedLine Citation:
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PMID: 17363064 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activity-dependent neuroprotective protein (ADNP) is essential for brain formation. The gene encoding ADNP is highly conserved and abundantly expressed in the brain. ADNP contains a homeobox profile and a peptide motif providing neuroprotection against a variety of cytotoxic insults. ADNP mRNA and protein expression responds to brain injury and oscillates as a function of the estrus cycle. The plastic nature of ADNP expression is correlated with brain protection and an association between neuroendocrine regulation and neuroprotection is put forth with ADNP as a focal point. Further understanding of neuroprotective molecules should pave the path to better diagnostics and therapies. In this respect, structure-activity studies have identified a short 8 amino acid peptide in ADNP/NAPVSIPQ (NAP) that provides potent neuroprotection. NAP is currently in clinical development for neuroprotection. |
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Authors:
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Illana Gozes |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-02-01 |
Journal Detail:
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Title: Pharmacology & therapeutics Volume: 114 ISSN: 0163-7258 ISO Abbreviation: Pharmacol. Ther. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-19 Completed Date: 2007-06-21 Revised Date: 2011-07-13 |
Medline Journal Info:
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Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: England |
Other Details:
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Languages: eng Pagination: 146-54 Citation Subset: IM |
Affiliation:
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The Adams Super-Center for Brain Studies & Levi-Edersheim-Gitter fMRI Institute, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv 69978, Israel. igozes@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Injuries / drug therapy, genetics, physiopathology Disease Models, Animal Drug Design Gene Expression* Homeodomain Proteins / genetics, physiology* Mice Nerve Tissue Proteins / genetics, physiology* Neuroprotective Agents / pharmacology*, therapeutic use Oligopeptides / pharmacology*, therapeutic use Rats Vasoactive Intestinal Peptide |
| Chemical | |
Reg. No./Substance:
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0/ADNP protein, human; 0/Adnp protein, mouse; 0/Homeodomain Proteins; 0/NAPVSIPQ peptide; 0/Nerve Tissue Proteins; 0/Neuroprotective Agents; 0/Oligopeptides; 37221-79-7/Vasoactive Intestinal Peptide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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