Document Detail


Activity-dependent neuronal signalling and autism spectrum disorder.
MedLine Citation:
PMID:  23325215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.
Authors:
Daniel H Ebert; Michael E Greenberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature     Volume:  493     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-03-04     Revised Date:  2014-01-24    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-37     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Child
Child Development Disorders, Pervasive / genetics,  pathology*,  physiopathology*
Gene Expression Regulation
Humans
Neuronal Plasticity
Neurons / physiology*
Signal Transduction*
Synapses / metabolism
Grant Support
ID/Acronym/Agency:
K08 MH090306/MH/NIMH NIH HHS; K08MH90306/MH/NIMH NIH HHS; R01 NS048276/NS/NINDS NIH HHS; R01NS048276/NS/NINDS NIH HHS
Comments/Corrections

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