| Activity-dependent neuronal signalling and autism spectrum disorder. | |
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MedLine Citation:
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PMID: 23325215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder. |
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Authors:
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Daniel H Ebert; Michael E Greenberg |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nature Volume: 493 ISSN: 1476-4687 ISO Abbreviation: Nature Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-17 Completed Date: 2013-03-04 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0410462 Medline TA: Nature Country: England |
Other Details:
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Languages: eng Pagination: 327-37 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child Child Development Disorders, Pervasive / genetics, pathology*, physiopathology* Gene Expression Regulation Humans Neuronal Plasticity Neurons / physiology* Signal Transduction* Synapses / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K08MH90306/MH/NIMH NIH HHS; R01 NS048276/NS/NINDS NIH HHS; R01NS048276/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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