Document Detail


Activity-dependent changes in the intrinsic properties of cultured neurons.
MedLine Citation:
PMID:  8178157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Learning and memory arise through activity-dependent modifications of neural circuits. Although the activity dependence of synaptic efficacy has been studied extensively, less is known about how activity shapes the intrinsic electrical properties of neurons. Lobster stomatogastric ganglion neurons fire in bursts when receiving synaptic and modulatory input but fire tonically when pharmacologically isolated. Long-term isolation in culture changed their intrinsic activity from tonic firing to burst firing. Rhythmic stimulation reversed this transition through a mechanism that was mediated by a rise in intracellular calcium concentration. These data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation.
Authors:
G Turrigiano; L F Abbott; E Marder
Related Documents :
9108207 - Neuronal gagging activity patterns may be generated by neurons in the reticular area do...
6600637 - Effects of some antiepileptic drugs on the repetitive activity of the node of ranvier.
6478207 - Activity of hypothalamic thermosensitive neurons during cortical spreading depression i...
2282517 - Cardiovascular-related discharge of periaqueductal gray neurons during sleep-waking sta...
1374347 - Retrograde transport of d-[3h]-aspartate injected into the monkey amygdaloid complex.
15528107 - Lateralisation of nociceptive processing in the human brain: a functional magnetic reso...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  264     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-09     Completed Date:  1994-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  974-7     Citation Subset:  IM    
Affiliation:
Department of Biology, Brandeis University, Waltham, MA 02254.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / physiology
Cells, Cultured
Egtazic Acid / analogs & derivatives,  pharmacology
Electric Stimulation
Electrophysiology
Ganglia, Invertebrate / cytology
Membrane Potentials
Nephropidae
Neurites / physiology
Neurons / cytology,  physiology*
Synapses / physiology
Grant Support
ID/Acronym/Agency:
MH46742/MH/NIMH NIH HHS; NS17813/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
67-42-5/Egtazic Acid; 7440-70-2/Calcium; 85233-19-8/1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cloning of a Grb2 isoform with apoptotic properties.
Next Document:  Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons.