| Activity-dependent changes in the intrinsic properties of cultured neurons. | |
| | |
MedLine Citation:
|
PMID: 8178157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Learning and memory arise through activity-dependent modifications of neural circuits. Although the activity dependence of synaptic efficacy has been studied extensively, less is known about how activity shapes the intrinsic electrical properties of neurons. Lobster stomatogastric ganglion neurons fire in bursts when receiving synaptic and modulatory input but fire tonically when pharmacologically isolated. Long-term isolation in culture changed their intrinsic activity from tonic firing to burst firing. Rhythmic stimulation reversed this transition through a mechanism that was mediated by a rise in intracellular calcium concentration. These data suggest that neurons regulate their conductances to maintain stable activity patterns and that the intrinsic properties of a neuron depend on its recent history of activation. |
| | |
Authors:
|
G Turrigiano; L F Abbott; E Marder |
Related Documents
:
|
9108207 - Neuronal gagging activity patterns may be generated by neurons in the reticular area do... 6600637 - Effects of some antiepileptic drugs on the repetitive activity of the node of ranvier. 6478207 - Activity of hypothalamic thermosensitive neurons during cortical spreading depression i... 2282517 - Cardiovascular-related discharge of periaqueductal gray neurons during sleep-waking sta... 1374347 - Retrograde transport of d-[3h]-aspartate injected into the monkey amygdaloid complex. 15528107 - Lateralisation of nociceptive processing in the human brain: a functional magnetic reso... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 264 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1994 May |
Date Detail:
|
Created Date: 1994-06-09 Completed Date: 1994-06-09 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 974-7 Citation Subset: IM |
Affiliation:
|
Department of Biology, Brandeis University, Waltham, MA 02254. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Calcium / physiology Cells, Cultured Egtazic Acid / analogs & derivatives, pharmacology Electric Stimulation Electrophysiology Ganglia, Invertebrate / cytology Membrane Potentials Nephropidae Neurites / physiology Neurons / cytology, physiology* Synapses / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
MH46742/MH/NIMH NIH HHS; NS17813/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
67-42-5/Egtazic Acid; 7440-70-2/Calcium; 85233-19-8/1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cloning of a Grb2 isoform with apoptotic properties.
Next Document: Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons.