| Activity of cecropin P1 and FA-LL-37 against urogenital microflora. | |
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MedLine Citation:
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PMID: 10955957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two mammalian antimicrobial peptides, FA-LL-37 and cecropin P1, were tested for activity against six uropathogens and five Lactobacillus strains by broth microdilution assay. Both peptides inhibited Escherichia coli at 25 microM (FA-LL-39), and 1.56 microM (cecropin P1), Pseudomonas aeruginosa (12.5 microM, and 25 microM), and Klebsiella pneumoniae, (50 microM, and 1.56 microM), but not Enterococcus faecalis and Staphylococcus epidermidis. FA-LL-37 acted bacteriocidally against E. coli and bacteriostatically against the other two Gram-negative organisms. Cecropin P1 was bacteriocidal to all susceptible bacteria. Lactobacilli were resistant to both peptides, with the exception of poultry isolate Lactobacillus fermentum B-54, which was susceptible to FA-LL-37 at 100 microM. The differential activities of these peptides toward Gram-negative uropathogens versus urogenital lactobacilli demonstrate their potential as a topical treatment for urinary tract infections. In addition, production of such peptides in vivo could be a natural mechanism to aid in the maintenance of the lactobacilli-dominated urogenital flora at the expense of pathogens. |
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Authors:
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V Smeianov; K Scott; G Reid |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Microbes and infection / Institut Pasteur Volume: 2 ISSN: 1286-4579 ISO Abbreviation: Microbes Infect. Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-11-15 Completed Date: 2001-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: FRANCE |
Other Details:
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Languages: eng Pagination: 773-7 Citation Subset: IM |
Affiliation:
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Lawson Research Institute, University of Western Ontario, London, ON, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Anti-Bacterial Agents / pharmacology* Antimicrobial Cationic Peptides* Carrier Proteins / pharmacology* Colony Count, Microbial Enterobacteriaceae / drug effects*, growth & development, isolation & purification Humans Lactobacillus / drug effects*, growth & development, isolation & purification Microbial Sensitivity Tests Molecular Sequence Data Peptides* Pilot Projects Urogenital System / microbiology* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Antimicrobial Cationic Peptides; 0/Carrier Proteins; 0/Peptides; 0/cathelicidin antimicrobial peptide; 0/cecropin P1-LI; 143108-26-3/CAP18 lipopolysaccharide-binding protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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