Document Detail


Activity assessment of eosinophilic esophagitis.
MedLine Citation:
PMID:  24603389     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The activity of eosinophilic esophagitis (EoE) can be assessed with patient-reported outcomes and biologic measures. Patient-reported outcomes include symptoms and quality of life, whereas biologic measures refer to endoscopic, histologic, and biochemical activity (e.g. blood biomarkers). So far, a validated tool to assess EoE activity in the above-mentioned dimensions is lacking. Given the lack of a standardized way to assess EoE activity in the various dimensions, the results of different clinical trials may be difficult to compare. For symptom assessment in adult patients, the symptom 'dysphagia' should be evaluated according to different standardized food consistencies. Furthermore, symptom assessment should take into account the following items: avoidance of specific food categories, food modification, and time to eat a regular meal. A distinct symptom recall period (e.g. 2 weeks) has to be defined for symptom assessment. Performing an 'esophageal stress test' with ingestion of a standardized meal to measure symptom severity bears the potential risk of acute food bolus impaction and should therefore be avoided. The description of endoscopic findings in EoE has meanwhile been standardized. Histologic evaluation of EoE activity should report either the size of the high-power field used or count the eosinophils per mm(2). There is a current lack of blood biomarkers demonstrating a good correlation with histologic activity in esophageal biopsies. The development and validation of an adult and pediatric EoE activity index is urgently needed not only for clinical trials and observational studies, but also for daily practice. © 2014 S. Karger AG, Basel.
Authors:
Alain Schoepfer; Ekaterina Safroneeva
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Publication Detail:
Type:  Journal Article     Date:  2014-02-28
Journal Detail:
Title:  Digestive diseases (Basel, Switzerland)     Volume:  32     ISSN:  1421-9875     ISO Abbreviation:  Dig Dis     Publication Date:  2014  
Date Detail:
Created Date:  2014-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701186     Medline TA:  Dig Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  98-101     Citation Subset:  IM    
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